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Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Mus musculus (house mouse) ]

Gene ID: 22186, updated on 5-Mar-2024

Summary

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Official Symbol
Uba52provided by MGI
Official Full Name
ubiquitin A-52 residue ribosomal protein fusion product 1provided by MGI
Primary source
MGI:MGI:98887
See related
Ensembl:ENSMUSG00000090137 AllianceGenome:MGI:98887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubb; Ubc; Cep52; Gm1863; Rps27a; D8Ertd21e
Summary
Predicted to enable protein tag and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Located in synapse. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 805.6), colon adult (RPKM 792.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70960913..70963067, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70508263..70510417, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 1 Neighboring gene required for excision 1-B domain containing Neighboring gene RIKEN cDNA 4930522P08 gene Neighboring gene STARR-positive B cell enhancer ABC_E5013 Neighboring gene KxDL motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_21774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease. Tiwari S, et al. Cells, 2022 Nov 25. PMID 36497031, Free PMC Article
  2. Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear. Kitoh R, et al. Neuroreport, 2007 Jun 11. PMID 17515792
  3. Ubiquitin and the enigma of intracellular protein degradation. Jennissen HP. Eur J Biochem, 1995 Jul 1. PMID 7628459
  4. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Kobayashi M, et al. Sci Rep, 2016 Nov 10. PMID 27829658, Free PMC Article
  5. A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Suzuki N, et al. FEBS J, 2016 Jun. PMID 27062441

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
    Title: UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.
  2. UbA52 may have a functional role in regulation of ion secretion in the inner ear
    Title: Immunocytochemical localization of ubiquitin A-52 protein in the mouse inner ear.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107645

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-ribosomal protein eL40 fusion protein
Names
60S ribosomal protein L40
ubiquitin-60S ribosomal protein L40
ubiquitin/60S ribosomal fusion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348227.1 → NP_001335156.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

    Status: VALIDATED

    Source sequence(s)
    AA271295, AC157774, CK334428
    Consensus CDS
    CCDS22371.1
    UniProtKB/Swiss-Prot
    P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
    UniProtKB/TrEMBL
    Q5M9K3
    Related
    ENSMUSP00000080608.5, ENSMUST00000081940.11
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

  2. NM_001348228.1 → NP_001335157.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

    Status: VALIDATED

    Source sequence(s)
    AA271295, AC157774, BQ746688
    Consensus CDS
    CCDS22371.1
    UniProtKB/Swiss-Prot
    P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
    UniProtKB/TrEMBL
    Q5M9K3
    Related
    ENSMUSP00000121149.2, ENSMUST00000129909.8
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

  3. NM_001348229.1 → NP_001335158.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

    Status: VALIDATED

    Source sequence(s)
    AA271295, AC157774, BQ746688, EH108858
    Consensus CDS
    CCDS22371.1
    UniProtKB/Swiss-Prot
    P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
    UniProtKB/TrEMBL
    Q5M9K3
    Related
    ENSMUSP00000137461.2, ENSMUST00000165126.9
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

  4. NM_019883.4 → NP_063936.1  ubiquitin-ribosomal protein eL40 fusion protein precursor

    See identical proteins and their annotated locations for NP_063936.1

    Status: VALIDATED

    Source sequence(s)
    AA271295, AC157774, AK018726
    Consensus CDS
    CCDS22371.1
    UniProtKB/Swiss-Prot
    P62984, P62991, Q62317, Q64223, Q8VCH1, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
    UniProtKB/TrEMBL
    Q5M9K3
    Related
    ENSMUSP00000120096.2, ENSMUST00000125184.8
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79 → 126
    Ribosomal_L40e; Ribosomal L40e family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70960913..70963067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62984.2 GenPept UniProtKB/Swiss-Prot:P62984

Gene LinkOut

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