Tyrp1 tyrosinase-related protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tyrp1provided by MGI
Official Full Name: tyrosinase-related protein 1provided by MGI
Primary source: MGI:MGI:98881
See related: Ensembl:ENSMUSG00000005994 AllianceGenome:MGI:98881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: b; isa; Oca3; TRP1; Tyrp; TRP-1; brown
Summary: Enables protein homodimerization activity. Involved in positive regulation of melanin biosynthetic process. Acts upstream of or within several processes, including acetoacetic acid metabolic process; melanocyte differentiation; and melanosome organization. Located in melanosome membrane. Is expressed in several structures, including hip; nervous system; sensory organ; skeleton; and skin. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 C3; 4 37.89 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (80752360..80769973)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (80834123..80851736)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase.
Title: Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase.
Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.
Title: Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice.
the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells
Title: Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells.
Studied upregulation by Kaliziri extract of tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.
Title: Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.
The SNARE machinery composed of VAMP7 on Tyrp1-containing vesicles and syntaxin-3 and SNAP23 on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Title: Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytes.
Addition of a TRP-1-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.
Title: Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma.
analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage
Title: Tyrosinase-related protein1 in mouse melanocytes at early embryonic stage.
GILT-deficient mice have an increase in TRP1-specific regulatory T (Treg) cells compared with TRP1-deficient mice, and depletion of Treg cells partially restores the ability of GILT-deficient TRP1-specific CD4(+) T cells to induce vitiligo.
Title: GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.
Title: Complex interactions of Tyrp1 in the eye.
DNA vaccination with a melanoma-shared antigen Trp1, combined with systemic TGF-beta blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.
Title: Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-β blockade during the perioperative period of tumor resection.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (8) 1 citation
Chemically induced (other) (14) 1 citation
Chemically and radiation induced (1)
Chemically induced (ENU) (10)
Radiation induced (28) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

PMC169968P1 (e-PCR)
- UniSTS:271616

PMC169968P2 (e-PCR)
- UniSTS:271617

X03687 (e-PCR)
- UniSTS:163343

Tyrp1 (e-PCR), detects polymorphism
- UniSTS:144715

X03687 (e-PCR)
- UniSTS:125782

Tyrp1 (e-PCR), detects polymorphism
- UniSTS:516184

Tyrp1 (e-PCR), detects polymorphism
- UniSTS:547477

D4Mit174 (e-PCR), detects polymorphism
- UniSTS:129953

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables tyrosinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetoacetic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in melanin biosynthetic process from tyrosine	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within melanin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Names: DHICA oxidase; brown locus protein; catalase B; iris stromal atrophy

NP_001268943.1

EC 1.14.18.-

NP_001268944.1

EC 1.14.18.-

NP_112479.1

EC 1.14.18.-

XP_006537844.1

EC 1.14.18.-

XP_006537845.1

EC 1.14.18.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282014.1 → NP_001268943.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

See identical proteins and their annotated locations for NP_001268943.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK148332, AL670884, BC076598

Consensus CDS

CCDS18290.1

UniProtKB/Swiss-Prot

P07147

UniProtKB/TrEMBL

Q3UFK6, Q3UFS3

Conserved Domains (1) summary

pfam00264
Location:183 → 417

Tyrosinase; Common central domain of tyrosinase
NM_001282015.1 → NP_001268944.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

See identical proteins and their annotated locations for NP_001268944.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK148332, AL670884, X03687

Consensus CDS

CCDS18290.1

UniProtKB/Swiss-Prot

P07147

UniProtKB/TrEMBL

Q3UFK6, Q3UFS3

Related

ENSMUSP00000099895.2, ENSMUST00000102831.8

Conserved Domains (1) summary

pfam00264
Location:183 → 417

Tyrosinase; Common central domain of tyrosinase
NM_031202.3 → NP_112479.1 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor

See identical proteins and their annotated locations for NP_112479.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK148332, AL670884, BC076598

Consensus CDS

CCDS18290.1

UniProtKB/Swiss-Prot

P07147

UniProtKB/TrEMBL

Q3UFK6, Q3UFS3

Related

ENSMUSP00000006151.7, ENSMUST00000006151.13

Conserved Domains (1) summary

pfam00264
Location:183 → 417

Tyrosinase; Common central domain of tyrosinase