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FCGR3B Fc gamma receptor IIIb [ Homo sapiens (human) ]

Gene ID: 2215, updated on 11-Apr-2024

Summary

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Official Symbol
FCGR3Bprovided by HGNC
Official Full Name
Fc gamma receptor IIIbprovided by HGNC
Primary source
HGNC:HGNC:3620
See related
Ensembl:ENSG00000162747 MIM:610665; AllianceGenome:HGNC:3620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD16; FCG3; CD16A; CD16b; FCGR3; CD16-I; FCGR3A; FCR-10; FCRIII; FCRIIIb
Summary
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Expression
Biased expression in spleen (RPKM 53.3), appendix (RPKM 50.9) and 7 other tissues See more
Orthologs
all
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Genomic context

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Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161623196..161631963, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160967541..160976307, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161592986..161601753, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161581576-161582270 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161582271-161582964 Neighboring gene tRNA-Leu (anticodon CAA) 6-1 Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 4269 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161608151-161608340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility. Aslam MM, et al. Genes (Basel), 2022 Nov 29. PMID 36553504, Free PMC Article
  2. Low-affinity immunoglobulin gamma Fc region receptor III-B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders. Minguela A, et al. Br J Haematol, 2021 Dec. PMID 34544201
  3. Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis. Xiang Y, et al. Int J Med Sci, 2020. PMID 32922178, Free PMC Article
  4. Aberrant FcγRIIb and FcγRIII expression on monocytes from patients with Behçet's disease. Huang L, et al. Clin Immunol, 2020 Oct. PMID 32739412
  5. FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis. Alberici F, et al. Rheumatology (Oxford), 2020 Nov 1. PMID 32375167

See all (213) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
    Title: Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility.
  2. Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
    Title: Single-cell analyses identify dysfunctional CD16(+) CD8 T cells in smokers.
  3. Significant differences in FcgammaRIIa, FcgammaRIIIa and FcgammaRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
    Title: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.
  4. Low-affinity immunoglobulin gamma Fc region receptor III-B (FcgammaRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
    Title: Low-affinity immunoglobulin gamma Fc region receptor III-B (FcγRIIIB, CD16B) deficiency in patients with blood and immune system disorders.
  5. The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
    Title: The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.
  6. Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
    Title: Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.
  7. FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
    Title: FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.
  8. Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
    Title: Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
  9. Aberrant FcgammaRIIb and FcgammaRIII expression on monocytes from patients with Behcet's disease.
    Title: Aberrant FcγRIIb and FcγRIII expression on monocytes from patients with Behçet's disease.
  10. FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
    Title: FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis.
Submit: New GeneRIF Correction See all GeneRIFs (132)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Tat tat HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages PubMed
tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables IgG binding IEA
Inferred from Electronic Annotation
more info
  
enables IgG receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in antibody-dependent cellular cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
low affinity immunoglobulin gamma Fc region receptor III-B
Names
Fc fragment of IgG receptor IIIb
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc gamma receptor III-B
Fc-gamma receptor IIIb (CD 16)
FcgammaRIIIb
fc-gamma RIII-beta
fc-gamma RIIIb
igG Fc receptor III-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032926.2 RefSeqGene

    Range
    5788..13768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1238

mRNA and Protein(s)

  1. NM_000570.5 → NP_000561.3  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

    See identical proteins and their annotated locations for NP_000561.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AL451067
    Consensus CDS
    CCDS41433.1
    UniProtKB/Swiss-Prot
    O75015
    UniProtKB/TrEMBL
    A0A3B3ISU3, Q9UPY7
    Related
    ENSP00000356941.2, ENST00000367964.6
    Conserved Domains (2) summary
    cd05752
    Location:26 → 104
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:108 → 190
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

  2. NM_001244753.2 → NP_001231682.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (2). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AJ581669, AL451067, M24854, X16863
    Consensus CDS
    CCDS41433.1
    UniProtKB/Swiss-Prot
    O75015
    UniProtKB/TrEMBL
    A0A3B3ISU3, Q9UPY7
    Related
    ENSP00000497461.1, ENST00000650385.1
    Conserved Domains (2) summary
    cd05752
    Location:26 → 104
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:108 → 190
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

  3. NM_001271035.2 → NP_001257964.2  low affinity immunoglobulin gamma Fc region receptor III-B isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is one aa shorter compared to isoform 2.
    Source sequence(s)
    AJ581669, AK316565, AL451067, DA673839
    Consensus CDS
    CCDS91090.1
    UniProtKB/TrEMBL
    H0Y4U3, Q9UPY7
    Related
    ENSP00000394204.3, ENST00000421702.4
    Conserved Domains (2) summary
    cd05752
    Location:25 → 103
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:107 → 189
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

  4. NM_001271036.2 → NP_001257965.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL451067
    UniProtKB/TrEMBL
    Q9UPY7
    Conserved Domains (2) summary
    cd05752
    Location:9 → 87
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:91 → 173
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

  5. NM_001271037.2 → NP_001257966.1  low affinity immunoglobulin gamma Fc region receptor III-B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL451067
    UniProtKB/Swiss-Prot
    O75015
    UniProtKB/TrEMBL
    A0A087WU90
    Conserved Domains (1) summary
    cd05752
    Location:9 → 87
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161623196..161631963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160967541..160976307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75015.3 GenPept UniProtKB/Swiss-Prot:O75015

Gene LinkOut

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