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Tgoln1 trans-golgi network protein [ Mus musculus (house mouse) ]

Gene ID: 22134, updated on 8-Feb-2024

Summary

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Official Symbol
Tgoln1provided by MGI
Official Full Name
trans-golgi network proteinprovided by MGI
Primary source
MGI:MGI:105080
See related
Ensembl:ENSMUSG00000056429 AllianceGenome:MGI:105080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGN38; Ttgn1; TGN38A; D6Ertd384e
Summary
Located in endosome and trans-Golgi network. Is expressed in dorsal root ganglion. Orthologous to human TGOLN2 (trans-golgi network protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 72.1), kidney adult (RPKM 45.3) and 28 other tissues See more
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Genomic context

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Location:
6 C1; 6 32.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72585403..72593983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72608420..72617000, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene retinol saturase (all trans retinol 13,14 reductase) Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box) Neighboring gene predicted gene 15401 Neighboring gene predicted gene, 31391 Neighboring gene 60S ribosomal protein L37 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation. Chen L, et al. Cell Cycle, 2014. PMID 25486359, Free PMC Article
  2. Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse. Kasai K, et al. J Biol Chem, 1995 Jun 16. PMID 7540170
  3. Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Steveson TC, et al. Endocrinology, 2003 Jan. PMID 12488345
  4. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Urushitani M, et al. Nat Neurosci, 2006 Jan. PMID 16369483
  5. LDL receptor related protein 1 requires the I(3) domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B. Mills J, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31487503, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGN38 may regulate the metaphase I/anaphase I transition and asymmetric cell division in mouse oocytes.
    Title: TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trans-Golgi network integral membrane protein 1
Names
trans-golgi network protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009443.3 → NP_033469.1  trans-Golgi network integral membrane protein 1 precursor

    See identical proteins and their annotated locations for NP_033469.1

    Status: VALIDATED

    Source sequence(s)
    AC125039, AK076586
    Consensus CDS
    CCDS51811.1
    UniProtKB/Swiss-Prot
    Q62313
    UniProtKB/TrEMBL
    Q3ULZ6, Q4FJY3
    Related
    ENSMUSP00000068487.5, ENSMUST00000070524.5
    Conserved Domains (1) summary
    PRK13108
    Location:99 → 285
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72585403..72593983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62313.1 GenPept UniProtKB/Swiss-Prot:Q62313

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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