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Ttc3 tetratricopeptide repeat domain 3 [ Mus musculus (house mouse) ]

Gene ID: 22129, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc3provided by MGI
Official Full Name
tetratricopeptide repeat domain 3provided by MGI
Primary source
MGI:MGI:1276539
See related
Ensembl:ENSMUSG00000040785 AllianceGenome:MGI:1276539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TPRD; D16Ium21; D16Ium21e; mKIAA4119; 2610202A04Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within negative regulation of cell morphogenesis involved in differentiation and negative regulation of neuron differentiation. Located in vacuole. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TTC3 (tetratricopeptide repeat domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 35.1), whole brain E14.5 (RPKM 30.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 55.18 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94171479..94270081)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94370625..94469222)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5565 Neighboring gene predicted gene, 53180 Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene predicted gene, 23692 Neighboring gene predicted gene, 31323 Neighboring gene STARR-positive B cell enhancer ABC_E1498 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene STARR-positive B cell enhancer ABC_E9431 Neighboring gene STARR-seq mESC enhancer starr_41576 Neighboring gene STARR-seq mESC enhancer starr_41578 Neighboring gene STARR-positive B cell enhancer ABC_E5566 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 1a Neighboring gene STARR-positive B cell enhancer mm9_chr16:94853523-94853824 Neighboring gene predicted gene, 53922

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1. Lopes C, et al. Mech Dev, 1999 Jun. PMID 10473140
  2. Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome. Tsukahara F, et al. J Biochem, 1998 Jun. PMID 9603993
  3. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3. Endo R, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36917672, Free PMC Article
  4. An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome. Guedj F, et al. Sci Rep, 2016 Sep 2. PMID 27586445, Free PMC Article
  5. The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. Berto G, et al. J Cell Sci, 2007 Jun 1. PMID 17488780

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
    Title: Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
  2. USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome.
    Title: An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.
  3. These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
    Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4119

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TTC3
Names
RING-type E3 ubiquitin transferase TTC3
TPR repeat protein D
mtprd
NP_033467.2
XP_006523047.1
XP_006523048.1
XP_006523049.1
XP_006523050.1
XP_006523051.1
XP_006523052.1
XP_006523053.1
XP_006523054.1
XP_006523055.1
XP_006523056.1
XP_006523057.1
XP_006523058.1
XP_006523059.1
XP_006523060.1
XP_006523062.1
XP_006523063.1
XP_011244415.1
XP_017172428.1
XP_017172429.1
XP_017172430.1
XP_017172431.1
XP_030104906.1
XP_030104907.1
XP_030104908.1
XP_030104909.1
XP_030104910.1
XP_030104911.1
XP_030104912.1
XP_030104913.1
XP_030104914.1
XP_030104915.1
XP_030104916.1
XP_030104917.1
XP_030104918.1
XP_030104919.1
XP_030104921.1
XP_036015769.1
XP_036015770.1
XP_036015771.1
XP_036015772.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009441.2 → NP_033467.2  E3 ubiquitin-protein ligase TTC3

    See identical proteins and their annotated locations for NP_033467.2

    Status: VALIDATED

    Source sequence(s)
    AC173208
    Consensus CDS
    CCDS37407.1
    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    UniProtKB/TrEMBL
    G5E8T2
    Related
    ENSMUSP00000112801.2, ENSMUST00000117648.9
    Conserved Domains (5) summary
    PTZ00121
    Location:1460 → 1694
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:237 → 381
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:232 → 259
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1930 → 1970
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:578 → 605
    TPR_1; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    94171479..94270081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522997.5 → XP_006523060.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    See identical proteins and their annotated locations for XP_006523060.1

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  2. XM_006522995.4 → XP_006523058.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    See identical proteins and their annotated locations for XP_006523058.1

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  3. XM_006523000.5 → XP_006523063.1  E3 ubiquitin-protein ligase TTC3 isoform X15

    See identical proteins and their annotated locations for XP_006523063.1

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:974 → 1208
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1444 → 1484
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat

  4. XM_006522999.4 → XP_006523062.1  E3 ubiquitin-protein ligase TTC3 isoform X15

    See identical proteins and their annotated locations for XP_006523062.1

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:974 → 1208
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1444 → 1484
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat

  5. XM_006522992.4 → XP_006523055.1  E3 ubiquitin-protein ligase TTC3 isoform X9

    See identical proteins and their annotated locations for XP_006523055.1

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (6) summary
    PTZ00121
    Location:1330 → 1564
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:107 → 251
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:102 → 129
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:410 → 472
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1800 → 1840
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:448 → 475
    TPR_1; Tetratricopeptide repeat

  6. XM_017316939.3 → XP_017172428.1  E3 ubiquitin-protein ligase TTC3 isoform X11

    UniProtKB/TrEMBL
    A0A338P6W3
    Related
    ENSMUSP00000156137.2, ENSMUST00000231569.2
    Conserved Domains (5) summary
    PTZ00121
    Location:1150 → 1384
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:181 → 208
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:230 → 292
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1620 → 1660
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:268 → 295
    TPR_1; Tetratricopeptide repeat

  7. XM_030249047.2 → XP_030104907.1  E3 ubiquitin-protein ligase TTC3 isoform X12

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:1149 → 1383
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:181 → 208
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:230 → 292
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1619 → 1659
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:268 → 295
    TPR_1; Tetratricopeptide repeat

  8. XM_006522996.4 → XP_006523059.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    See identical proteins and their annotated locations for XP_006523059.1

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  9. XM_030249055.2 → XP_030104915.1  E3 ubiquitin-protein ligase TTC3 isoform X14

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1058 → 1292
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1528 → 1568
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  10. XM_006522988.3 → XP_006523051.1  E3 ubiquitin-protein ligase TTC3 isoform X6

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1459 → 1693
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:237 → 381
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:232 → 259
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1929 → 1969
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:578 → 605
    TPR_1; Tetratricopeptide repeat

  11. XM_006522989.4 → XP_006523052.1  E3 ubiquitin-protein ligase TTC3 isoform X7

    See identical proteins and their annotated locations for XP_006523052.1

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1442 → 1676
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:219 → 363
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:214 → 241
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1912 → 1952
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:560 → 587
    TPR_1; Tetratricopeptide repeat

  12. XM_006522990.2 → XP_006523053.1  E3 ubiquitin-protein ligase TTC3 isoform X8

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1441 → 1675
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:219 → 363
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:214 → 241
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1911 → 1951
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:560 → 587
    TPR_1; Tetratricopeptide repeat

  13. XM_006522994.3 → XP_006523057.1  E3 ubiquitin-protein ligase TTC3 isoform X11

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:1150 → 1384
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:181 → 208
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:230 → 292
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1620 → 1660
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:268 → 295
    TPR_1; Tetratricopeptide repeat

  14. XM_017316940.2 → XP_017172429.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  15. XM_030249061.1 → XP_030104921.1  E3 ubiquitin-protein ligase TTC3 isoform X16

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:973 → 1207
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1443 → 1483
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:136 → 251
    DUF5861; Family of unknown function (DUF5861)

  16. XM_006522984.4 → XP_006523047.1  E3 ubiquitin-protein ligase TTC3 isoform X1

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1479 → 1713
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:256 → 400
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:251 → 278
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1949 → 1989
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:597 → 624
    TPR_1; Tetratricopeptide repeat

  17. XM_006522985.1 → XP_006523048.1  E3 ubiquitin-protein ligase TTC3 isoform X3

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1479 → 1712
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:256 → 400
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:251 → 278
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1948 → 1988
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:597 → 624
    TPR_1; Tetratricopeptide repeat

  18. XM_006522986.1 → XP_006523049.1  E3 ubiquitin-protein ligase TTC3 isoform X2

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1478 → 1712
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:256 → 400
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:251 → 278
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1948 → 1988
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:597 → 624
    TPR_1; Tetratricopeptide repeat

  19. XM_036159877.1 → XP_036015770.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  20. XM_017316941.2 → XP_017172430.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  21. XM_030249056.2 → XP_030104916.1  E3 ubiquitin-protein ligase TTC3 isoform X14

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1058 → 1292
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1528 → 1568
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  22. XM_017316942.2 → XP_017172431.1  E3 ubiquitin-protein ligase TTC3 isoform X16

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:973 → 1207
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1443 → 1483
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:136 → 251
    DUF5861; Family of unknown function (DUF5861)

  23. XM_030249054.1 → XP_030104914.1  E3 ubiquitin-protein ligase TTC3 isoform X14

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1058 → 1292
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1528 → 1568
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  24. XM_006522993.3 → XP_006523056.1  E3 ubiquitin-protein ligase TTC3 isoform X10

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (6) summary
    PTZ00121
    Location:1312 → 1546
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:89 → 233
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:84 → 111
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:392 → 454
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1782 → 1822
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:430 → 457
    TPR_1; Tetratricopeptide repeat

  25. XM_006522987.3 → XP_006523050.1  E3 ubiquitin-protein ligase TTC3 isoform X4

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (5) summary
    PTZ00121
    Location:1461 → 1695
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:238 → 382
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:233 → 260
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1931 → 1971
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:579 → 606
    TPR_1; Tetratricopeptide repeat

  26. XM_030249048.1 → XP_030104908.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  27. XM_036159878.1 → XP_036015771.1  E3 ubiquitin-protein ligase TTC3 isoform X14

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1058 → 1292
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1528 → 1568
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  28. XM_030249057.1 → XP_030104917.1  E3 ubiquitin-protein ligase TTC3 isoform X15

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:974 → 1208
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1444 → 1484
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat

  29. XM_036159879.1 → XP_036015772.1  E3 ubiquitin-protein ligase TTC3 isoform X16

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:973 → 1207
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1443 → 1483
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:136 → 251
    DUF5861; Family of unknown function (DUF5861)

  30. XM_030249050.1 → XP_030104910.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  31. XM_030249052.1 → XP_030104912.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  32. XM_030249058.1 → XP_030104918.1  E3 ubiquitin-protein ligase TTC3 isoform X15

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:974 → 1208
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1444 → 1484
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat

  33. XM_030249051.1 → XP_030104911.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  34. XM_030249059.1 → XP_030104919.1  E3 ubiquitin-protein ligase TTC3 isoform X15

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (5) summary
    PTZ00121
    Location:974 → 1208
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:5 → 32
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:54 → 116
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1444 → 1484
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:92 → 119
    TPR_1; Tetratricopeptide repeat

  35. XM_006522991.3 → XP_006523054.1  E3 ubiquitin-protein ligase TTC3 isoform X9

    See identical proteins and their annotated locations for XP_006523054.1

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (6) summary
    PTZ00121
    Location:1330 → 1564
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:107 → 251
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:102 → 129
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:410 → 472
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1800 → 1840
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:448 → 475
    TPR_1; Tetratricopeptide repeat

  36. XM_030249046.1 → XP_030104906.1  E3 ubiquitin-protein ligase TTC3 isoform X10

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    Conserved Domains (6) summary
    PTZ00121
    Location:1312 → 1546
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:89 → 233
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:84 → 111
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:392 → 454
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1782 → 1822
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:430 → 457
    TPR_1; Tetratricopeptide repeat

  37. XM_030249049.1 → XP_030104909.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  38. XM_036159876.1 → XP_036015769.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  39. XM_030249053.1 → XP_030104913.1  E3 ubiquitin-protein ligase TTC3 isoform X13

    UniProtKB/TrEMBL
    A0A338P6W3
    Conserved Domains (6) summary
    PTZ00121
    Location:1059 → 1293
    PTZ00121; MAEBL; Provisional
    sd00006
    Location:90 → 117
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:139 → 201
    TPR_12; Tetratricopeptide repeat
    cd16481
    Location:1529 → 1569
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:177 → 204
    TPR_1; Tetratricopeptide repeat
    pfam19179
    Location:221 → 336
    DUF5861; Family of unknown function (DUF5861)

  40. XM_011246113.4 → XP_011244415.1  E3 ubiquitin-protein ligase TTC3 isoform X5

    See identical proteins and their annotated locations for XP_011244415.1

    UniProtKB/Swiss-Prot
    O88196, Q05D15, Q3TMM9, Q3TPC8, Q3TPV5, Q3TQL0, Q3TSK0, Q3UFH5, Q5DTM5, Q6PG61, Q8BPM4, Q8C2N6
    UniProtKB/TrEMBL
    G5E8T2
    Related
    ENSMUSP00000156023.2, ENSMUST00000232395.2
    Conserved Domains (5) summary
    PTZ00121
    Location:1460 → 1694
    PTZ00121; MAEBL; Provisional
    PLN03088
    Location:237 → 381
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:232 → 259
    TPR; TPR repeat [structural motif]
    cd16481
    Location:1930 → 1970
    RING-H2_TTC3; RING finger, H2 subclass, found in Tetratricopeptide repeat protein 3 (TTC3) and similar proteins
    pfam00515
    Location:578 → 605
    TPR_1; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88196.2 GenPept UniProtKB/Swiss-Prot:O88196

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