Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd3provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3provided by MGI
Primary source: MGI:MGI:98858
See related: Ensembl:ENSMUSG00000017221 AllianceGenome:MGI:98858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Psd3; AntP91a; Tstap91a; D11Bwg1349e
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 118.0), ovary adult (RPKM 104.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.39 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98573380..98586804)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98682554..98695978)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tstap91a (e-PCR), detects polymorphism
- UniSTS:144694

Tstap91a (e-PCR), detects polymorphism
- UniSTS:144695

Tstap91a (e-PCR), detects polymorphism
- UniSTS:144696

AI255837 (e-PCR)
- UniSTS:180309

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D11Mit14 (e-PCR), detects polymorphism
- UniSTS:126332

UniSTS:224381 (e-PCR)
- UniSTS:224381

RH93398 (e-PCR)
- UniSTS:90256

S0040 (e-PCR), detects polymorphism
- UniSTS:253097

RH129390 (e-PCR)
- UniSTS:212697

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 3

Names: 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; proteasome subunit p58; tissue specific transplantation antigen P91A; transplantation antigen P91A; tum-P91A antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009439.1 → NP_033465.1 26S proteasome non-ATPase regulatory subunit 3

See identical proteins and their annotated locations for NP_033465.1

Status: VALIDATED

Source sequence(s)

BC003197

Consensus CDS

CCDS25359.1

UniProtKB/Swiss-Prot

P14685, Q3TP95, Q99LL7

UniProtKB/TrEMBL

Q8BK46

Related

ENSMUSP00000017365.9, ENSMUST00000017365.15

Conserved Domains (2) summary

pfam01399
Location:354 → 458

PCI; PCI domain

pfam08375
Location:461 → 519

Rpn3_C; Proteasome regulatory subunit C-terminal