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Phlda2 pleckstrin homology like domain, family A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22113, updated on 16-Apr-2024

Summary

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Official Symbol
Phlda2provided by MGI
Official Full Name
pleckstrin homology like domain, family A, member 2provided by MGI
Primary source
MGI:MGI:1202307
See related
Ensembl:ENSMUSG00000010760 AllianceGenome:MGI:1202307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ipl; Tssc3
Summary
This gene is one of several genes in the imprinted gene domain on chromosome 7. Studies using knockout mice have shown that the product of this gene regulates placental growth. Transcripts from this gene are most abundant in placenta and yolk sac, and are almost entirely transcribed from the maternal allele. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta adult (RPKM 163.8), kidney adult (RPKM 10.9) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.23 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143055282..143056882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143501545..143503145, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33663 Neighboring gene solute carrier family 22 (organic cation transporter), member 18 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297 Neighboring gene STARR-positive B cell enhancer ABC_E1362 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene microRNA 7064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse. Angiolini E, et al. Genes (Basel), 2021 Apr 25. PMID 33922969, Free PMC Article
  2. Maternal care boosted by paternal imprinting in mammals. Creeth HDJ, et al. PLoS Biol, 2018 Jul. PMID 30063711, Free PMC Article
  3. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Tunster SJ, et al. Dis Model Mech, 2014 Oct. PMID 25085993, Free PMC Article
  4. The expression of the imprinted gene Ipl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development. Dunwoodie SL, et al. Int J Dev Biol, 2002. PMID 12141432
  5. The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway. Takao T, et al. J Biol Chem, 2012 Dec 14. PMID 23071113, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
    Title: PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
  2. Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse.
    Title: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse.
  3. Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.
    Title: The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources.
  4. data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve
    Title: Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice.
  5. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway.
    Title: The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway.
  6. Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.
    Title: Placental growth retardation due to loss of imprinting of Phlda2.
  7. A critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta is identified.
    Title: The imprinted Phlda2 gene regulates extraembryonic energy stores.
  8. Embryonic expression of Ipl in mice
    Title: The expression of the imprinted gene Ipl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development.
  9. Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs.
    Title: Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1.
  10. deletion causes placental overgrowth
    Title: Placental overgrowth in mice lacking the imprinted gene Ipl.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in placenta development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within placenta development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of glycogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of growth hormone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology-like domain family A member 2
Names
imprinted in placenta and liver protein
protein 50C15
tumor-suppressing subchromosomal transferable fragment 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009434.2 → NP_033460.1  pleckstrin homology-like domain family A member 2

    See identical proteins and their annotated locations for NP_033460.1

    Status: REVIEWED

    Source sequence(s)
    CF615806, CF617643, Y15443
    Consensus CDS
    CCDS22042.1
    UniProtKB/Swiss-Prot
    O08969
    Related
    ENSMUSP00000010904.4, ENSMUST00000010904.5
    Conserved Domains (1) summary
    pfam17339
    Location:22 → 104
    DUF5369; Family of unknown function (DUF5369)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143055282..143056882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508597.2 → XP_006508660.1  pleckstrin homology-like domain family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006508660.1

    UniProtKB/Swiss-Prot
    O08969
    Conserved Domains (1) summary
    pfam17339
    Location:22 → 104
    DUF5369; Family of unknown function (DUF5369)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08969.1 GenPept UniProtKB/Swiss-Prot:O08969

Gene LinkOut

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