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UCMA upper zone of growth plate and cartilage matrix associated [ Homo sapiens (human) ]

Gene ID: 221044, updated on 5-Mar-2024

Summary

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Official Symbol
UCMAprovided by HGNC
Official Full Name
upper zone of growth plate and cartilage matrix associatedprovided by HGNC
Primary source
HGNC:HGNC:25205
See related
Ensembl:ENSG00000165623 AllianceGenome:HGNC:25205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRP; C10orf49; GRP/UCMA
Summary
This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
10p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (13221766..13234374, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (13234493..13247115, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (13263766..13276374, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:13203307-13203620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2151 Neighboring gene Sharpr-MPRA regulatory region 2216 Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene RNA, U6 small nuclear 6, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13276077-13276987 Neighboring gene phytanoyl-CoA 2-hydroxylase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:13341054-13341674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2152 Neighboring gene uncharacterized LOC124902377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3051 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:13343766-13344266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein). Viegas CSB, et al. Arterioscler Thromb Vasc Biol, 2018 Mar. PMID 29301790
  2. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. Viegas CSB, et al. PLoS One, 2017. PMID 28542410, Free PMC Article
  3. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cavaco S, et al. Cell Mol Life Sci, 2016 Mar. PMID 26337479
  4. Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism. Osman A, et al. Clin Lab, 2013. PMID 24409676
  5. Unique cartilage matrix-associated protein inhibits the migratory and invasive potential of triple-negative breast cancer. Lee SH, et al. Biochem Biophys Res Commun, 2020 Oct 1. PMID 32768190

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of emerging vitamin Kdependent proteins: Growth arrestspecific protein 6, Glarich protein and periostin (Review).
    Title: Role of emerging vitamin K‑dependent proteins: Growth arrest‑specific protein 6, Gla‑rich protein and periostin (Review).
  2. Unique cartilage matrix-associated protein inhibits the migratory and invasive potential of triple-negative breast cancer.
    Title: Unique cartilage matrix-associated protein inhibits the migratory and invasive potential of triple-negative breast cancer.
  3. Decreased levels of GRP and fetuin-A promote circulating calciprotein particle/extracellular vesicle mediated vascular calcification in chronic kidney disease.
    Title: Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).
  4. GRP might act as a novel molecular mediator linking inflammation and calcification events
    Title: Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.
  5. The study demonstrates the involvement of GRP in the two major molecular processes affecting osteoarthritis: mineralization and inflammation of articular tissue.
    Title: Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.
  6. Data suggest that novel splice variants of GRP are expressed in cartilage and other tissues (i.e. GRP-F5, GRP-F6); GRP-F1 is predominant splice variant expressed in adult tissues particularly in cartilage of patients with osteoarthritis.
    Title: Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status.
  7. full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population
    Title: Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism.
  8. Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla residues.
    Title: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.
  9. The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation.
    Title: Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes.
  10. Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells
    Title: Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unique cartilage matrix-associated protein
Names
Gla-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303118.2 → NP_001290047.1  unique cartilage matrix-associated protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001290047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA628504, AL138764, BC018068, JX169864
    UniProtKB/TrEMBL
    A0A067XJP8
    Conserved Domains (1) summary
    pfam17085
    Location:1 → 102
    UCMA; Unique cartilage matrix associated protein

  2. NM_001303119.2 → NP_001290048.1  unique cartilage matrix-associated protein isoform 3

    See identical proteins and their annotated locations for NP_001290048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA628504, AL138764, BC018068, JX169865
    UniProtKB/TrEMBL
    A0A067XKV3
    Conserved Domains (1) summary
    pfam17085
    Location:1 → 80
    UCMA; Unique cartilage matrix associated protein

  3. NM_145314.3 → NP_660357.2  unique cartilage matrix-associated protein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_660357.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA628504, AL138764, BC018068
    Consensus CDS
    CCDS31147.1
    UniProtKB/Swiss-Prot
    Q8WVF2
    UniProtKB/TrEMBL
    A0A067XJX6, R4GMV7
    Related
    ENSP00000367952.3, ENST00000378681.8
    Conserved Domains (1) summary
    pfam17085
    Location:1 → 134
    UCMA; Unique cartilage matrix associated protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    13221766..13234374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    13234493..13247115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WVF2.2 GenPept UniProtKB/Swiss-Prot:Q8WVF2

Gene LinkOut

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