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Rsph1 radial spoke head 1 homolog (Chlamydomonas) [ Mus musculus (house mouse) ]

Gene ID: 22092, updated on 5-Mar-2024

Summary

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Official Symbol
Rsph1provided by MGI
Official Full Name
radial spoke head 1 homolog (Chlamydomonas)provided by MGI
Primary source
MGI:MGI:1194909
See related
Ensembl:ENSMUSG00000024033 AllianceGenome:MGI:1194909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCA; Tsga2
Summary
Acts upstream of or within spermatid development. Located in condensed nuclear chromosome; cytoplasm; and cytoskeleton. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 217.4) See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 15.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31473993..31496270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31255019..31277296, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15318 Neighboring gene trefoil factor 1 Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a Primary Ciliary Dyskinesia Phenotype. Yin W, et al. Am J Respir Cell Mol Biol, 2019 Sep. PMID 30896965, Free PMC Article
  2. Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis. Tokuhiro K, et al. J Biol Chem, 2008 Jul 4. PMID 18453535
  3. MSAP, the meichroacidin homolog of carp (Cyprinus carpio), differs from the rodent counterpart in germline expression and involves flagellar differentiation. Ju TK, et al. Biol Reprod, 2004 Nov. PMID 15215198
  4. Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia. Yoke H, et al. PLoS Genet, 2020 Mar. PMID 32203505, Free PMC Article
  5. Molecular cloning and characterization of meichroacidin (male meiotic metaphase chromosome-associated acidic protein). Tsuchida J, et al. Dev Biol, 1998 May 1. PMID 9578619

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tsga2 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
  2. Tsga2 fulfills many of the prerequisites required to make it a strong candidate for Ccub1, an element of Cucb positioned within a genomic interval spanning approximately 0.6 Mb immediately distal to Dnahc8.
    Title: The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IC
Inferred by Curator
more info
 PubMed 
involved_in flagellated sperm motility IC
Inferred by Curator
more info
 PubMed 
involved_in mating IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in 9+2 motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer dense fiber IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke head IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke head 1 IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke head 3 IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
radial spoke head 1 homolog
Names
male meiotic metaphase chromosome-associated acidic protein
meichroacidin
testis-specific gene A2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364916.1 → NP_001351845.1  radial spoke head 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK005739, BP771558, DQ141555
    Consensus CDS
    CCDS89057.1
    UniProtKB/TrEMBL
    Q3YE99, Q3YEA0
    Related
    ENSMUSP00000158337.2, ENSMUST00000235144.2
    Conserved Domains (1) summary
    cl27415
    Location:19 → 149
    COG4642; Uncharacterized conserved protein [Function unknown]

  2. NM_025290.4 → NP_079566.1  radial spoke head 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_079566.1

    Status: VALIDATED

    Source sequence(s)
    AC154652
    Consensus CDS
    CCDS28604.1
    UniProtKB/Swiss-Prot
    Q8VIG3, Q9DAL5
    UniProtKB/TrEMBL
    Q3YEA4, Q3YEA6
    Related
    ENSMUSP00000024832.8, ENSMUST00000024832.9
    Conserved Domains (1) summary
    PLN03185
    Location:20 → 148
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31473993..31496270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VIG3.2 GenPept UniProtKB/Swiss-Prot:Q8VIG3

Gene LinkOut

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