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Tpt1 tumor protein, translationally-controlled 1 [ Mus musculus (house mouse) ]

Gene ID: 22070, updated on 21-Apr-2024

Summary

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Official Symbol
Tpt1provided by MGI
Official Full Name
tumor protein, translationally-controlled 1provided by MGI
Primary source
MGI:MGI:104890
See related
Ensembl:ENSMUSG00000060126 AllianceGenome:MGI:104890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trt; p21; p23; TCTP
Summary
Predicted to enable calcium ion binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in sciatic nerve and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1476.1), bladder adult (RPKM 983.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 40.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76082771..76085743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75845256..75848303)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37147 Neighboring gene predicted gene, 36271 Neighboring gene STARR-positive B cell enhancer ABC_E8900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:76234679-76234835 Neighboring gene STARR-positive B cell enhancer ABC_E9410 Neighboring gene predicted gene 4285 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene STARR-seq mESC enhancer starr_37150 Neighboring gene STARR-positive B cell enhancer ABC_E10835 Neighboring gene predicted gene, 52138 Neighboring gene STARR-seq mESC enhancer starr_37153 Neighboring gene general transcription factor IIF, polypeptide 2 Neighboring gene armadillo repeat containing 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). Morimoto Y, et al. Neurochem Res, 2022 Sep. PMID 35622214
  2. TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes. Jeon HJ, et al. J Cell Physiol, 2022 Jan. PMID 34407217
  3. Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice. Jeon Y, et al. Int J Obes (Lond), 2021 Jul. PMID 33931746, Free PMC Article
  4. Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis. Kim M, et al. Exp Mol Med, 2021 Jan. PMID 33408335, Free PMC Article
  5. Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling. Lin Z, et al. Cell Death Dis, 2020 Jan 23. PMID 31974368, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
    Title: TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
  2. Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani.
    Title: Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani.
  3. TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes.
    Title: TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes.
  4. Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis.
    Title: Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis.
  5. Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.
    Title: Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.
  6. TCTP is Essential for Cell Proliferation and Survival during CNS Development.
    Title: TCTP is Essential for Cell Proliferation and Survival during CNS Development.
  7. Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling.
    Title: Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling.
  8. The biological effects of Na,K-ATPase and TCTP interaction are reviewed.
    Title: Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP).
  9. that TPT1 knockdown altered the BECN1 interactome, a representative MTOR-independent pathway, to stimulate autophagosome formation
    Title: TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
  10. The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure.
    Title: Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ectoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
translationally-controlled tumor protein
Names
21 kDa polypeptide under translational control
fortilin
translationally regulated transcript (21 kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424592.1 → NP_001411521.1  translationally-controlled tumor protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140244

  2. NM_009429.4 → NP_033455.1  translationally-controlled tumor protein isoform 1

    See identical proteins and their annotated locations for NP_033455.1

    Status: VALIDATED

    Source sequence(s)
    AC140244
    Consensus CDS
    CCDS36980.1
    UniProtKB/Swiss-Prot
    P63028, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9
    UniProtKB/TrEMBL
    D3YU75
    Related
    ENSMUSP00000106519.3, ENSMUST00000110894.9
    Conserved Domains (1) summary
    pfam00838
    Location:1 → 167
    TCTP; Translationally controlled tumor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    76082771..76085743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63028.1 GenPept UniProtKB/Swiss-Prot:P63028

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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