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FCER1G Fc epsilon receptor Ig [ Homo sapiens (human) ]

Gene ID: 2207, updated on 7-Apr-2024

Summary

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Official Symbol
FCER1Gprovided by HGNC
Official Full Name
Fc epsilon receptor Igprovided by HGNC
Primary source
HGNC:HGNC:3611
See related
Ensembl:ENSG00000158869 MIM:147139; AllianceGenome:HGNC:3611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRG
Summary
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 140.4), spleen (RPKM 128.5) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161215295..161219245)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160352747..160356700)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161185085..161189035)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161146985-161147484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161148623-161149124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1983 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161162728-161163541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161166678-161167583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161170109-161170830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1985 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161187006-161187992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1987 Neighboring gene apolipoprotein A2 Neighboring gene translocase of outer mitochondrial membrane 40 like Neighboring gene microRNA 5187

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of FCER1G as a key gene in multiple myeloma based on weighted gene co-expression network analysis. Qiu X, et al. Hematology, 2023 Dec. PMID 37170758
  2. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. Shemesh A, et al. J Exp Med, 2022 Nov 7. PMID 36066491, Free PMC Article
  3. Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment. Yang R, et al. Immunology, 2023 Feb. PMID 36054819
  4. Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma. Chen L, et al. Int J Biol Sci, 2017. PMID 29209141, Free PMC Article
  5. Regulation of FcRγ function by site-specific serine phosphorylation. Shah S, et al. J Leukoc Biol, 2017 Feb. PMID 27630214, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of FCER1G as a cyclosporin A plus corticosteroid sensitization gene in female patients with Vogt-Koyanagi-Harada disease.
    Title: Identification of FCER1G as a cyclosporin A plus corticosteroid sensitization gene in female patients with Vogt-Koyanagi-Harada disease.
  2. Identification of FCER1G as a key gene in multiple myeloma based on weighted gene co-expression network analysis.
    Title: Identification of FCER1G as a key gene in multiple myeloma based on weighted gene co-expression network analysis.
  3. Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment.
    Title: Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment.
  4. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcepsilonRIgamma expression.
    Title: Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.
  5. The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration.
    Title: The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration.
  6. Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis.
    Title: Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis.
  7. FCER1G and PTGS2 Serve as Potential Diagnostic Biomarkers of Acute Myocardial Infarction Based on Integrated Bioinformatics Analyses.
    Title: FCER1G and PTGS2 Serve as Potential Diagnostic Biomarkers of Acute Myocardial Infarction Based on Integrated Bioinformatics Analyses.
  8. Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcepsilonRIgamma and NKG2C.
    Title: Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C.
  9. FCER1G was identified and validated in association with ccRCC progression and prognosis, which might improve the prognosis by influencing immune-related pathways
    Title: Co-expression network analysis identified FCER1G in association with progression and prognosis in human clear cell renal cell carcinoma.
  10. mass spectrometry of WT human FcRgamma from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51.
    Title: Regulation of FcRγ function by site-specific serine phosphorylation.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgE binding IEA
Inferred from Electronic Annotation
more info
  
enables IgE receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Fc-epsilon receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Fc-gamma receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-3-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fc-gamma receptor III complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
high affinity immunoglobulin epsilon receptor subunit gamma
Names
Fc fragment of IgE receptor Ig
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Fc receptor gamma-chain
FcepsilonRI gamma chain
FcepsilonRIgamma
fc-epsilon RI-gamma
fcRgamma
fceRI gamma
immunoglobulin E receptor, high affinity, gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029043.1 RefSeqGene

    Range
    4999..8949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004106.2 → NP_004097.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

    See identical proteins and their annotated locations for NP_004097.1

    Status: REVIEWED

    Source sequence(s)
    AL590714, M33195
    Consensus CDS
    CCDS1225.1
    UniProtKB/Swiss-Prot
    P30273, Q5VTW4
    Related
    ENSP00000289902.1, ENST00000289902.2
    Conserved Domains (2) summary
    smart00077
    Location:62 → 82
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:21 → 51
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161215295..161219245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160352747..160356700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30273.1 GenPept UniProtKB/Swiss-Prot:P30273

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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