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Trpc3 transient receptor potential cation channel, subfamily C, member 3 [ Mus musculus (house mouse) ]

Gene ID: 22065, updated on 11-Apr-2024

Summary

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Official Symbol
Trpc3provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 3provided by MGI
Primary source
MGI:MGI:109526
See related
Ensembl:ENSMUSG00000027716 AllianceGenome:MGI:109526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mwk; Trp3; Trcp3; Trrp3
Summary
Predicted to enable calcium activated cation channel activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Predicted to be involved in several processes, including metal ion transport; positive regulation of cardiac muscle hypertrophy in response to stress; and response to ATP. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. Is expressed in cochlea; ganglia; limb; spinal cord; and trunk somite. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 16.9), CNS E18 (RPKM 4.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 B; 3 17.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (36674626..36744276, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (36620482..36690429, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2068 Neighboring gene exosome component 9 Neighboring gene STARR-seq mESC enhancer starr_07426 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene predicted gene, 35856 Neighboring gene STARR-seq mESC enhancer starr_07428 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 pseudogene Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene STARR-seq mESC enhancer starr_07429 Neighboring gene STARR-seq mESC enhancer starr_07431

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ablation of TRPC3 disrupts Ca(2+) signaling in salivary ductal cells and promotes sialolithiasis. Choi BE, et al. Sci Rep, 2023 Apr 8. PMID 37031239, Free PMC Article
  2. Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice. Chen M, et al. J Cell Mol Med, 2022 Oct. PMID 36029194, Free PMC Article
  3. Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling. Zhao Y, et al. J Am Heart Assoc, 2022 Aug 2. PMID 35904193, Free PMC Article
  4. Sensory neuron-expressed TRPC3 mediates acute and chronic itch. Liu Y, et al. Pain, 2023 Jan 1. PMID 35507377
  5. A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice. Lu M, et al. Curr Med Sci, 2020 Dec. PMID 33428139

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New insights in the renal distribution profile of TRPC3 - Of mice and men.
    Title: New insights in the renal distribution profile of TRPC3 - Of mice and men.
  2. Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
    Title: Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.
  3. Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
    Title: Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice.
  4. Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
    Title: Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
  5. TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
    Title: TRPC3 Regulates Islet Beta-Cell Insulin Secretion.
  6. Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
    Title: Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells.
  7. Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in alpha-synuclein transgenic mice.
    Title: Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice.
  8. Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
    Title: Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt-Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling.
  9. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
    Title: A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
  10. TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons.
    Title: TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124333

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 3
Names
TRP-3
mTrp3
receptor-activated cation channel TRP3
transient receptor protein 3
trp-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403842.1 → NP_001390771.1  short transient receptor potential channel 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117584

  2. NM_019510.3 → NP_062383.2  short transient receptor potential channel 3 isoform 1

    See identical proteins and their annotated locations for NP_062383.2

    Status: VALIDATED

    Source sequence(s)
    AC117584
    Consensus CDS
    CCDS50893.1
    UniProtKB/Swiss-Prot
    B1ATV3, Q61058, Q9QZC1
    UniProtKB/TrEMBL
    Q8CCQ1
    Related
    ENSMUSP00000029271.5, ENSMUST00000029271.5
    Conserved Domains (4) summary
    cd00204
    Location:108 → 242
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:85 → 879
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:256 → 315
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:135 → 166
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    36674626..36744276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZC1.2 GenPept UniProtKB/Swiss-Prot:Q9QZC1

Gene LinkOut

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