Trpc2 transient receptor potential cation channel, subfamily C, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc2provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 2provided by MGI
Primary source: MGI:MGI:109527
See related: Ensembl:ENSMUSG00000100254 AllianceGenome:MGI:109527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: trp2; Trrp2; mTrp2; TRPC2a; TRPC2b; smTRPC2; 3010009O07Rik
Summary: Enables several functions, including calmodulin binding activity; diacylglycerol binding activity; and inositol 1,4,5 trisphosphate binding activity. Acts upstream of or within several processes, including inter-male aggressive behavior; mating behavior; and territorial aggressive behavior. Located in several cellular components, including Golgi membrane; dendrite membrane; and nuclear envelope. Is expressed in brain; ganglia; genitourinary system; and sensory organ. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
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Genomic context

Location:: 7 E2; 7 54.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101732323..101746071)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102083116..102096864)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TRPC2 function in mice alters sex differences in brain regions regulating social behaviors.
Title: Loss of TRPC2 function in mice alters sex differences in brain regions regulating social behaviors.
Nucleus accumbens dopamine signaling regulates sexual preference for females in male mice via Trpc2.
Title: Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice.
Low oxygen induces calcium influx in a subpopulation of olfactory epithelium neurons, and Gucy1b2 and Trpc2 are required for these responses.
Title: A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.
The Trpc2(-/-) males housed under isolated conditions spent significantly longer in the vicinity of pups than did the Trpc2(-/-) males than had been group housed, whereas no isolation effect was observed in heterozygous Trpc2(+/-) males.
Title: Vomeronasal signal deficiency enhances parental behavior in socially isolated male mice.
Authors show that TrpC2(-/-) males were able to acquire aversion to female-soiled bedding and presented similar behavioral alterations following COA in their responses to female cues.
Title: Conditioned odor aversion induces social anxiety towards females in wild-type and TrpC2 knockout male mice.
Two types of neurons in the main olfactory epithelium express Trpc2.
Title: Trpc2-expressing sensory neurons in the main olfactory epithelium of the mouse.
The data demonstrate that TRPC2 plays an important role in oxidative stress-induced hemolysis, which may be related to reduced calcium entry in red cells in the presence of Trpc2 depletion.
Title: Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis.
In the medial and basolateral amygdala, KO mice showed a robust Fos response to bedding, suggesting that regions of the amygdala canonically associated with pheromonal sensing can be active in the brains of KO mice.
Title: Trpc2-deficient lactating mice exhibit altered brain and behavioral responses to bedding stimuli.
These data suggest that both diacylglycerol and its metabolite, arachidonic acid, mediate excitatory odor responses in the vomeronasal organ, by activating two types of channels, a TRPC2 and a separate Ca(2+)-permeable channel.
Title: Odors activate dual pathways, a TRPC2 and a AA-dependent pathway, in mouse vomeronasal neurons.
Loss of the Trpc2 gene severely diminishes maternal aggression. Deletion of the gene results in differential hypotrophy of the glomerular layer of the AOB.
Title: Trpc2 gene impacts on maternal aggression, accessory olfactory bulb anatomy and brain activity.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc2 (e-PCR), detects polymorphism
- UniSTS:546048

Trpc2 (e-PCR), detects polymorphism
- UniSTS:531239

Trrp2 (e-PCR), detects polymorphism
- UniSTS:144683

Trpc2 (e-PCR), detects polymorphism
- UniSTS:516711

Trpc2 (e-PCR), detects polymorphism
- UniSTS:516712

RH135897 (e-PCR)
- UniSTS:209895

Readthrough Xntrpc

Readthrough gene: Xntrpc, Included gene: Xndc1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables store-operated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables store-operated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mating behavior, sex discrimination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male mating behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in single strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within territorial aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short transient receptor potential channel 2

Names: transient receptor potential 2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109897.2 → NP_001103367.1 short transient receptor potential channel 2

Status: VALIDATED

Source sequence(s)

AC132297, AC150275

Consensus CDS

CCDS52333.1

UniProtKB/Swiss-Prot

Q9R244

Related

ENSMUSP00000116934.3, ENSMUST00000124189.3

Conserved Domains (4) summary

cd00204
Location:63 → 172

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:23 → 761

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:183 → 242

TRP_2; Transient receptor ion channel II

sd00045
Location:93 → 138

ANK; ANK repeat [structural motif]