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Traf3 TNF receptor-associated factor 3 [ Mus musculus (house mouse) ]

Gene ID: 22031, updated on 11-Apr-2024

Summary

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Official Symbol
Traf3provided by MGI
Official Full Name
TNF receptor-associated factor 3provided by MGI
Primary source
MGI:MGI:108041
See related
Ensembl:ENSMUSG00000021277 AllianceGenome:MGI:108041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN
Summary
Enables protein kinase binding activity. Involved in several processes, including regulation of defense response to virus; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 14.4), thymus adult (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Traf3 in Genome Data Viewer
Location:
12 F1; 12 60.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111132799..111233589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111166321..111267155)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112276930-112277113 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112277230-112277417 Neighboring gene STARR-positive B cell enhancer mm9_chr12:112283133-112283433 Neighboring gene predicted gene, 35846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112310033-112310280 Neighboring gene REST corepressor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7184 Neighboring gene DNA repair protein SWI5 homolog pseudogene Neighboring gene VISTA enhancer mm3 Neighboring gene RIKEN cDNA 4930595D18 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:112398161-112398462 Neighboring gene STARR-positive B cell enhancer ABC_E7186 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112477093-112477276 Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene predicted gene, 51960 Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnionless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion. Zhu S, et al. Front Immunol, 2023. PMID 37207205, Free PMC Article
  2. TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer. Zorea J, et al. J Exp Clin Cancer Res, 2023 May 1. PMID 37121997, Free PMC Article
  3. TRAF3: Guardian of T lymphocyte functions. Hornick EL, et al. Front Immunol, 2023. PMID 36814922, Free PMC Article
  4. TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-κB signaling pathway in mice. Sun XQ, et al. Gen Physiol Biophys, 2022 Mar. PMID 35416178
  5. TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination. Zhu S, et al. Clin Exp Hypertens, 2022 Jul 4. PMID 35318880

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
    Title: The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
  2. TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer.
    Title: TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer.
  3. Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
    Title: Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
  4. TRAF3: Guardian of T lymphocyte functions.
    Title: TRAF3: Guardian of T lymphocyte functions.
  5. TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-kappaB-inducing kinase-mediated hepatocyte transdifferentiation.
    Title: TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation.
  6. TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-kappaB signaling pathway in mice.
    Title: TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-κB signaling pathway in mice.
  7. SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.
    Title: SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.
  8. TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.
    Title: TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.
  9. MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
    Title: MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
  10. TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
    Title: TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TNF receptor-associated factor 3
Names
CD40 receptor-associated factor 1
CD40-binding protein
RING-type E3 ubiquitin transferase TRAF3
NP_001273051.1
NP_001351293.1
NP_001409354.1
NP_001409355.1
NP_035762.2
XP_006515862.1
XP_006515863.1
XP_006515865.1
XP_030102544.1
XP_036013273.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286122.1 → NP_001273051.1  TNF receptor-associated factor 3 isoform b

    See identical proteins and their annotated locations for NP_001273051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR and an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC122023, AK147362, BF661650
    Consensus CDS
    CCDS36563.1
    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Related
    ENSMUSP00000112517.2, ENSMUST00000117269.8
    Conserved Domains (4) summary
    COG1196
    Location:226 → 407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352 → 537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

  2. NM_001364364.1 → NP_001351293.1  TNF receptor-associated factor 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580, AK147362, CJ127244
    Consensus CDS
    CCDS36563.1
    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Related
    ENSMUSP00000058361.7, ENSMUST00000060274.7
    Conserved Domains (4) summary
    COG1196
    Location:226 → 407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352 → 537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

  3. NM_001422425.1 → NP_001409354.1  TNF receptor-associated factor 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380

  4. NM_001422426.1 → NP_001409355.1  TNF receptor-associated factor 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122023, AC127580
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380

  5. NM_011632.3 → NP_035762.2  TNF receptor-associated factor 3 isoform a

    See identical proteins and their annotated locations for NP_035762.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC122023, AK147362, BC137634, BF661650, CJ127244
    Consensus CDS
    CCDS26175.1
    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Related
    ENSMUSP00000021706.5, ENSMUST00000021706.11
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111132799..111233589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515802.3 → XP_006515865.1  TNF receptor-associated factor 3 isoform X2

    See identical proteins and their annotated locations for XP_006515865.1

    UniProtKB/TrEMBL
    Q3UHJ1, Q3UHM2
    Conserved Domains (4) summary
    COG1196
    Location:226 → 407
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:352 → 537
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

  2. XM_036157380.1 → XP_036013273.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  3. XM_006515800.3 → XP_006515863.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006515863.1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  4. XM_006515799.2 → XP_006515862.1  TNF receptor-associated factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006515862.1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

  5. XM_030246684.2 → XP_030102544.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B2RPW3, Q60803, Q62380
    UniProtKB/TrEMBL
    Q3UHM2
    Conserved Domains (5) summary
    COG1196
    Location:251 → 432
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:377 → 562
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:135 → 191
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:50 → 91
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:196 → 246
    zf-TRAF; TRAF-type zinc finger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048206.1: Suppressed sequence

    Description
    NM_001048206.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60803.2 GenPept UniProtKB/Swiss-Prot:Q60803

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