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ERICH6B glutamate rich 6B [ Homo sapiens (human) ]

Gene ID: 220081, updated on 5-Mar-2024

Summary

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Official Symbol
ERICH6Bprovided by HGNC
Official Full Name
glutamate rich 6Bprovided by HGNC
Primary source
HGNC:HGNC:26523
See related
Ensembl:ENSG00000165837 AllianceGenome:HGNC:26523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM194B
Expression
Restricted expression toward testis (RPKM 1.6) See more
Orthologs
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Genomic context

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Location:
13q14.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45541294..45615739, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44762627..44837047, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46115429..46189874, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:46058676-46059178 Neighboring gene component of oligomeric golgi complex 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46114323-46114822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46115537-46116388 Neighboring gene RNA, 5S ribosomal pseudogene 27 Neighboring gene TIMM9 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46189497-46189998 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:46232427-46233626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:46243444-46244066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46254125-46254627 Neighboring gene cytochrome c oxidase subunit 4I1 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1055 Neighboring gene aldo-keto reductase family 1 member B1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. Meng X, et al. J Biol Chem, 2012 Feb 10. PMID 22199357, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato G, et al. Sci Data, 2018 Mar 6. PMID 29509190, Free PMC Article
  4. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 194, member B (FAM194B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32682

General protein information

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Preferred Names
glutamate-rich protein 6B
Names
family with sequence similarity 194, member B
protein FAM194B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182542.3 → NP_872348.2  glutamate-rich protein 6B

    See identical proteins and their annotated locations for NP_872348.2

    Status: VALIDATED

    Source sequence(s)
    AL139326
    Consensus CDS
    CCDS45045.1
    UniProtKB/Swiss-Prot
    Q5W0A0, Q96MB5
    Related
    ENSP00000298738.2, ENST00000298738.3
    Conserved Domains (1) summary
    pfam14977
    Location:472 → 666
    FAM194; FAM194 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    45541294..45615739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020418.2 → XP_016875907.1  glutamate-rich protein 6B isoform X2

    UniProtKB/Swiss-Prot
    Q5W0A0, Q96MB5
    Conserved Domains (1) summary
    pfam14977
    Location:472 → 666
    FAM194; FAM194 protein

  2. XM_011534965.3 → XP_011533267.1  glutamate-rich protein 6B isoform X1

    See identical proteins and their annotated locations for XP_011533267.1

    Conserved Domains (1) summary
    pfam14977
    Location:472 → 690
    FAM194; FAM194 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    44762627..44837047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374192.1 → XP_054230167.1  glutamate-rich protein 6B isoform X2

  2. XM_054374191.1 → XP_054230166.1  glutamate-rich protein 6B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5W0A0.1 GenPept UniProtKB/Swiss-Prot:Q5W0A0

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