U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tpd52l1 tumor protein D52-like 1 [ Mus musculus (house mouse) ]

Gene ID: 21987, updated on 2-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tpd52l1provided by MGI
Official Full Name
tumor protein D52-like 1provided by MGI
Primary source
MGI:MGI:1298386
See related
Ensembl:ENSMUSG00000000296 AllianceGenome:MGI:1298386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D53
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in G2/M transition of mitotic cell cycle and positive regulation of signal transduction. Predicted to be located in early endosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in brain; limb bud; otic capsule; and temporal bone petrous part. Orthologous to human TPD52L1 (TPD52 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 17.3), ovary adult (RPKM 8.3) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 A4; 10 17.36 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31208369..31321989, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31332373..31445987, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene HD domain containing 2 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764 Neighboring gene ring finger protein 217 Neighboring gene STARR-seq mESC enhancer starr_26216 Neighboring gene high mobility group box 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro. Proux-Gillardeaux V, et al. Biochem J, 2003 Feb 15. PMID 12376003, Free PMC Article
  2. Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. Byrne JA, et al. Cytogenet Cell Genet, 1998. PMID 9730602
  3. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). Byrne JA, et al. Genomics, 1996 Aug 1. PMID 8812487
  4. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. Byrne JA, et al. Oncogene, 1998 Feb 19. PMID 9484778
  5. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Hoerder-Suabedissen A, et al. Proc Natl Acad Sci U S A, 2013 Feb 26. PMID 23401504, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tumor protein D53

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359364.2 → NP_001346293.1  tumor protein D53 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969
    Consensus CDS
    CCDS87983.1
    UniProtKB/TrEMBL
    B2RUC1
    Related
    ENSMUSP00000149177.2, ENSMUST00000213528.2
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 192
    TPD52; tumor protein D52 family

  2. NM_001359365.2 → NP_001346294.1  tumor protein D53 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 133
    TPD52; tumor protein D52 family

  3. NM_001359366.2 → NP_001346295.1  tumor protein D53 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969
    Consensus CDS
    CCDS87980.1
    UniProtKB/TrEMBL
    Q3V2G6
    Related
    ENSMUSP00000149749.2, ENSMUST00000214644.2
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 129
    TPD52; tumor protein D52 family

  4. NM_001428867.1 → NP_001415796.1  tumor protein D53 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969

  5. NM_001428868.1 → NP_001415797.1  tumor protein D53 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969

  6. NM_001428869.1 → NP_001415798.1  tumor protein D53 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969

  7. NM_009413.3 → NP_033439.1  tumor protein D53 isoform 2

    See identical proteins and their annotated locations for NP_033439.1

    Status: VALIDATED

    Source sequence(s)
    AC153729, AC153969
    Consensus CDS
    CCDS35877.1
    UniProtKB/Swiss-Prot
    O54818
    Related
    ENSMUSP00000000305.6, ENSMUST00000000305.7
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 187
    TPD52; Tumour protein D52 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    31208369..31321989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245062.2 → XP_030100922.1  tumor protein D53 isoform X1

    UniProtKB/TrEMBL
    A0A1L1ST53
    Related
    ENSMUSP00000150184.2, ENSMUST00000213639.2
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 174
    TPD52; tumor protein D52 family

  2. XM_030245063.2 → XP_030100923.1  tumor protein D53 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SR11
    Related
    ENSMUSP00000149266.2, ENSMUST00000215515.2
    Conserved Domains (1) summary
    pfam04201
    Location:12 → 131
    TPD52; tumor protein D52 family

  3. XM_030245064.2 → XP_030100924.1  tumor protein D53 isoform X3

    Conserved Domains (1) summary
    pfam04201
    Location:12 → 133
    TPD52; tumor protein D52 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54818.1 GenPept UniProtKB/Swiss-Prot:O54818

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous