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Tpbg trophoblast glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 21983, updated on 21-Apr-2024

Summary

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Official Symbol
Tpbgprovided by MGI
Official Full Name
trophoblast glycoproteinprovided by MGI
Primary source
MGI:MGI:1341264
See related
Ensembl:ENSMUSG00000035274 AllianceGenome:MGI:1341264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5T4; WAIF1
Summary
Acts upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Located in several cellular components, including axon terminus; dendrite; and endoplasmic reticulum. Is expressed in several structures, including brain; epithelium; extraembryonic component; skin; and urinary system. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.0), limb E14.5 (RPKM 6.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.1; 9 46.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (85724433..85729110)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (85842380..85847057)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24823 Neighboring gene RIKEN cDNA 9330154J02 gene Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24825 Neighboring gene STARR-seq mESC enhancer starr_24827 Neighboring gene STARR-seq mESC enhancer starr_24828 Neighboring gene STARR-seq mESC enhancer starr_24829 Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae. Takahashi Y, et al. Front Cell Neurosci, 2019. PMID 31417363, Free PMC Article
  2. 5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb. Yoshihara S, et al. J Neurosci, 2012 Feb 8. PMID 22323733, Free PMC Article
  3. A leucine-rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb. Imamura F, et al. J Comp Neurol, 2006 Apr 20. PMID 16506198
  4. The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency. Ward CM, et al. J Cell Sci, 2003 Nov 15. PMID 14576347
  5. Expression and distribution of trophoblast glycoprotein in the mouse retina. Wakeham CM, et al. J Comp Neurol, 2020 Jul. PMID 31891182, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the binding of osteoclast-derived CTHRC1 to WAIF1 in stromal cells activates PKCdelta-ERK osteoblastogenic signaling.
    Title: WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.
  2. The surface expression of 5T4 marks the use of the CXCR4 rather than the CXCR7 receptor, with distinct consequences for CXCL12 exposure.
    Title: CXCL12 receptor preference, signal transduction, biological response and the expression of 5T4 oncofoetal glycoprotein.
  3. 5T4 overexpression in newborn olfactory bulb interneurons facilitates their dendritic arborization even under a sensory input-deprived condition.
    Title: 5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb.
  4. molecular interaction of 5T4 and CXCR4 occurring at the cell surface which directly facilitates the biological response to CXCL12
    Title: CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.
  5. Spry4 and Tpbg/5T4 were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.
    Title: Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
  6. E-cadherin protein stabilizes cortical actin cytoskeletal arrangement in embryonic stem cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.
    Title: E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.
  7. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen
    Title: Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen.
  8. 5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells
    Title: The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency.
  9. Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons.
    Title: A leucine-rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb.
  10. A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis
    Title: Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesenchymal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
trophoblast glycoprotein
Names
5T4 oncofetal antigen
5T4 oncofetal trophoblast glycoprotein
5T4 oncotrophoblast glycoprotein
wnt-activated inhibitory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164792.1 → NP_001158264.1  trophoblast glycoprotein precursor

    See identical proteins and their annotated locations for NP_001158264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC158516, AK143519
    Consensus CDS
    CCDS23380.1
    UniProtKB/Swiss-Prot
    Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
    Related
    ENSMUSP00000096101.4, ENSMUST00000098500.5
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:217 → 276
    LRR_8; Leucine rich repeat

  2. NM_011627.4 → NP_035757.2  trophoblast glycoprotein precursor

    See identical proteins and their annotated locations for NP_035757.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC158516, AK051162
    Consensus CDS
    CCDS23380.1
    UniProtKB/Swiss-Prot
    Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
    Related
    ENSMUSP00000006559.8, ENSMUST00000006559.14
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:217 → 276
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    85724433..85729110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313282.3 → XP_017168771.1  trophoblast glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:217 → 276
    LRR_8; Leucine rich repeat

  2. XM_017313281.2 → XP_017168770.1  trophoblast glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:217 → 276
    LRR_8; Leucine rich repeat

  3. XM_017313280.2 → XP_017168769.1  trophoblast glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:217 → 276
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0L0.3 GenPept UniProtKB/Swiss-Prot:Q9Z0L0

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