U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppp1r13b protein phosphatase 1, regulatory subunit 13B [ Mus musculus (house mouse) ]

Gene ID: 21981, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ppp1r13bprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 13Bprovided by MGI
Primary source
MGI:MGI:1336199
See related
Ensembl:ENSMUSG00000021285 AllianceGenome:MGI:1336199
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p85; ASPP1; Tp53bp2; Trp53bp2
Summary
Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including blood; brain; cardiovascular system; embryo mesenchyme; and yolk sac. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 13.8), genital fat pad adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 F1; 12 61.14 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111794892..111874549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111828457..111908119, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene predicted gene, 53769 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113090021-113090249 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene Neighboring gene predicted gene, 57592 Neighboring gene predicted gene, 40898 Neighboring gene high mobility group box 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury. Yang Y, et al. Circ Res, 2023 Jan 20. PMID 36656967, Free PMC Article
  2. Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation. Yamashita M, et al. Cell Stem Cell, 2015 Jul 2. PMID 26119234
  3. Gene-trap expression screening to identify endothelial-specific genes. Hirashima M, et al. Blood, 2004 Aug 1. PMID 15090446
  4. ASPP: a new family of oncogenes and tumour suppressor genes. Sullivan A, et al. Br J Cancer, 2007 Jan 29. PMID 17211478, Free PMC Article
  5. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Fang DF, et al. Nat Commun, 2014 Jul 29. PMID 25072696

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
    Title: Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
  2. After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC) cycling and induces p53-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC self-renewal and accumulation of DNA damage in p53 null HSCs.
    Title: Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.
  3. Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of retinal ganglion cells.
    Title: ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.
  4. Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53-independent manner.
    Title: Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
apoptosis-stimulating of p53 protein 1
Names
protein phosphatase 1, regulatory (inhibitor) subunit 13B
transformation related protein 53 binding protein 2
tumor protein p53 binding protein, 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011625.1 → NP_035755.1  apoptosis-stimulating of p53 protein 1

    See identical proteins and their annotated locations for NP_035755.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054788
    Consensus CDS
    CCDS56866.1
    UniProtKB/Swiss-Prot
    Q62415
    UniProtKB/TrEMBL
    A0A1Y7VJH3
    Related
    ENSMUSP00000062464.8, ENSMUST00000054815.15
    Conserved Domains (7) summary
    cd00204
    Location:883 → 1006
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam07321
    Location:154 → 317
    YscO; Type III secretion protein YscO
    pfam12796
    Location:889 → 975
    Ank_2; Ankyrin repeats (3 copies)
    pfam13863
    Location:153 → 247
    DUF4200; Domain of unknown function (DUF4200)
    sd00045
    Location:889 → 915
    ANK; ANK repeat [structural motif]
    cl09111
    Location:208 → 318
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl17036
    Location:1019 → 1075
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111794892..111874549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515796.5 → XP_006515859.1  apoptosis-stimulating of p53 protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VJH3
    Conserved Domains (6) summary
    PHA03247
    Location:479 → 895
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:153 → 329
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:924 → 950
    ANK; ANK repeat [structural motif]
    cd17224
    Location:2 → 86
    RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
    pfam12796
    Location:924 → 1010
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:1054 → 1110
    SH3; Src Homology 3 domain superfamily

  2. XM_006515797.5 → XP_006515860.1  apoptosis-stimulating of p53 protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VJH3
    Related
    ENSMUSP00000152424.2, ENSMUST00000220486.2
    Conserved Domains (6) summary
    PHA03247
    Location:476 → 892
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:150 → 326
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:921 → 947
    ANK; ANK repeat [structural motif]
    cd17224
    Location:1 → 83
    RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
    pfam12796
    Location:921 → 1007
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:1051 → 1107
    SH3; Src Homology 3 domain superfamily

  3. XM_030246683.2 → XP_030102543.1  apoptosis-stimulating of p53 protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VJH3
    Conserved Domains (6) summary
    PHA03247
    Location:441 → 857
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:150 → 326
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00045
    Location:886 → 912
    ANK; ANK repeat [structural motif]
    cd17224
    Location:1 → 83
    RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
    pfam12796
    Location:886 → 972
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:1016 → 1072
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62415.2 GenPept UniProtKB/Swiss-Prot:Q62415

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous