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Tnnt1 troponin T1, skeletal, slow [ Mus musculus (house mouse) ]

Gene ID: 21955, updated on 3-Apr-2024

Summary

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Official Symbol
Tnnt1provided by MGI
Official Full Name
troponin T1, skeletal, slowprovided by MGI
Primary source
MGI:MGI:1333868
See related
Ensembl:ENSMUSG00000064179 AllianceGenome:MGI:1333868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tnt; sTnT; ssTnT
Summary
This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Expression
Biased expression in limb E14.5 (RPKM 26.9), CNS E11.5 (RPKM 6.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Tnnt1 in Genome Data Viewer
Location:
7 A1; 7 2.6 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4507568..4518974, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4504569..4515975, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3 Neighboring gene synaptotagmin V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy. Oki K, et al. J Physiol, 2019 Aug. PMID 31148174, Free PMC Article
  2. Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand. Ara MN, et al. Cancer Med, 2014 Aug. PMID 24810801, Free PMC Article
  3. The expression of Troponin T1 gene is induced by ketamine in adult mouse brain. Lowe XR, et al. Brain Res, 2007 Oct 12. PMID 17850769
  4. Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene. Huang QQ, et al. Gene, 1999 Mar 18. PMID 10095098
  5. Three alternatively spliced mouse slow skeletal muscle troponin T isoforms: conserved primary structure and regulated expression during postnatal development. Jin JP, et al. Gene, 1998 Jul 3. PMID 9651500

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy.
    Title: The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy.
  2. Similar functional and histological phenotypes were observed in other human cohorts and two transgenic murine models (Tnnt1-/- and Tnnt1 c.505G>T). These findings have implications for emerging molecular therapies, including the suitably of TNNT1 gene replacement for newborns with 'Amish' nemaline myopathy or other TNNT1-associated myopathies.
    Title: TNNT1 nemaline myopathy: natural history and therapeutic frontier.
  3. Mouse tumor endothelial cells express troponin T.
    Title: Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand.
  4. demonstrated that ssTnT deficiency resulted in significantly decreased levels of other slow fibre-specific myofilament proteins whereas fast fibre-specific myofilament proteins were increased correspondingly
    Title: Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue.
  5. Data show that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles.
    Title: Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
  6. the induction of Tnnt1 gene expression in adult mouse brains by ketamine may illustrate the genes involved in the metabolic syndromes observed in neuropsychiatric disorders
    Title: The expression of Troponin T1 gene is induced by ketamine in adult mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
  
enables troponin T binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin T binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in slow-twitch skeletal muscle fiber contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in slow-twitch skeletal muscle fiber contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
troponin T, slow skeletal muscle
Names
skeletal muscle slow-twitch TnT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277903.1 → NP_001264832.1  troponin T, slow skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_001264832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS71880.1
    UniProtKB/Swiss-Prot
    B7ZNV5, B7ZNV6, O88346, O88795, Q9QUP7
    UniProtKB/TrEMBL
    J3QPC8
    Related
    ENSMUSP00000104228.3, ENSMUST00000108587.9
    Conserved Domains (1) summary
    pfam00992
    Location:69 → 205
    Troponin

  2. NM_001277904.1 → NP_001264833.1  troponin T, slow skeletal muscle isoform 3

    See identical proteins and their annotated locations for NP_001264833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3, also known as low Mr isoform), compared to isoform 1.
    Source sequence(s)
    AC161218
    Consensus CDS
    CCDS71879.1
    UniProtKB/TrEMBL
    B7ZNV4
    Related
    ENSMUSP00000129626.2, ENSMUST00000163710.8
    Conserved Domains (1) summary
    pfam00992
    Location:57 → 193
    Troponin

  3. NM_001360154.1 → NP_001347083.1  troponin T, slow skeletal muscle isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC161218
    UniProtKB/TrEMBL
    J3QPC8
    Related
    ENSMUSP00000128476.2, ENSMUST00000166268.8
    Conserved Domains (1) summary
    pfam00992
    Location:58 → 194
    Troponin

  4. NM_001417401.1 → NP_001404330.1  troponin T, slow skeletal muscle isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC161218

  5. NM_001417402.1 → NP_001404331.1  troponin T, slow skeletal muscle isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC161218

  6. NM_011618.2 → NP_035748.1  troponin T, slow skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_035748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as high Mr isoform 2), compared to isoform 1.
    Source sequence(s)
    AK160226
    Consensus CDS
    CCDS51973.1
    UniProtKB/TrEMBL
    J3QPC8, Q3TVB8
    Related
    ENSMUSP00000071704.7, ENSMUST00000071798.13
    Conserved Domains (1) summary
    pfam00992
    Location:68 → 204
    Troponin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4507568..4518974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322114.2 → XP_017177603.1  troponin T, slow skeletal muscle isoform X4

    UniProtKB/TrEMBL
    B7ZNV4
    Conserved Domains (1) summary
    pfam00992
    Location:97 → 233
    Troponin

  2. XM_017322113.2 → XP_017177602.1  troponin T, slow skeletal muscle isoform X3

    UniProtKB/TrEMBL
    J3QPC8
    Conserved Domains (1) summary
    pfam00992
    Location:98 → 234
    Troponin

  3. XM_017322112.2 → XP_017177601.1  troponin T, slow skeletal muscle isoform X2

    UniProtKB/TrEMBL
    J3QPC8
    Conserved Domains (1) summary
    pfam00992
    Location:108 → 244
    Troponin

  4. XM_017322111.2 → XP_017177600.1  troponin T, slow skeletal muscle isoform X1

    UniProtKB/TrEMBL
    J3QPC8
    Conserved Domains (1) summary
    pfam00992
    Location:109 → 245
    Troponin

  5. XM_011250478.3 → XP_011248780.1  troponin T, slow skeletal muscle isoform X6

    UniProtKB/TrEMBL
    J3QPC8
    Conserved Domains (1) summary
    pfam00992
    Location:88 → 224
    Troponin

  6. XM_011250477.3 → XP_011248779.1  troponin T, slow skeletal muscle isoform X5

    Conserved Domains (1) summary
    pfam00992
    Location:89 → 225
    Troponin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88346.3 GenPept UniProtKB/Swiss-Prot:O88346

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