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LRRC55 leucine rich repeat containing 55 [ Homo sapiens (human) ]

Gene ID: 219527, updated on 5-Mar-2024

Summary

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Official Symbol
LRRC55provided by HGNC
Official Full Name
leucine rich repeat containing 55provided by HGNC
Primary source
HGNC:HGNC:32324
See related
Ensembl:ENSG00000183908 MIM:615213; AllianceGenome:HGNC:32324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 2.8), lymph node (RPKM 1.5) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57181953..57191717)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57131394..57141139)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (56949427..56959191)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369309 Neighboring gene olfactory receptor family 5 subfamily AO member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily BP member 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:56891940-56892583 Neighboring gene Sharpr-MPRA regulatory region 9255 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:56954263-56954427 Neighboring gene Sharpr-MPRA regulatory region 8342 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:56980775-56981308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:56981309-56981843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57004366-57004998 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:57008040-57008806 Neighboring gene Sharpr-MPRA regulatory region 4343 Neighboring gene uncharacterized LOC107984364 Neighboring gene apelin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes. Hu S, et al. J Exp Med, 2021 Mar 1. PMID 33346797, Free PMC Article
  2. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits. Li Q, et al. J Gen Physiol, 2015 Jun. PMID 26009545, Free PMC Article
  3. Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation. Zhou Y, et al. Cell Res, 2019 Aug. PMID 31213650, Free PMC Article
  4. BK potassium channel modulation by leucine-rich repeat-containing proteins. Yan J, et al. Proc Natl Acad Sci U S A, 2012 May 15. PMID 22547800, Free PMC Article
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
    Title: Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes.
  2. Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation.
    Title: Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation.
  3. Suggest that BK channel modulation by auxiliary gamma subunits depends on intra- and/or juxta-membrane mechanisms.
    Title: Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13339, FLJ45686, DKFZp667D0425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 55
Names
BK channel auxiliary gamma subunit LRRC55
BK channel auxilliary gamma snit LRRC55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005210.4 → NP_001005210.2  leucine-rich repeat-containing protein 55 precursor

    Status: VALIDATED

    Source sequence(s)
    AK023401, AK127591, AP001786
    Consensus CDS
    CCDS31539.2
    UniProtKB/Swiss-Prot
    A7E2U7, B2RN81, Q6ZSA7
    UniProtKB/TrEMBL
    A0A494C0H1
    Related
    ENSP00000419542.2, ENST00000497933.3
    Conserved Domains (4) summary
    PLN00113
    Location:47 → 201
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:47 → 66
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:90 → 148
    LRR_8; Leucine rich repeat
    cl15307
    Location:196 → 247
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57181953..57191717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57131394..57141139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZSA7.3 GenPept UniProtKB/Swiss-Prot:Q6ZSA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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