Cd70 CD70 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd70provided by MGI
Official Full Name: CD70 antigenprovided by MGI
Primary source: MGI:MGI:1195273
See related: Ensembl:ENSMUSG00000019489 AllianceGenome:MGI:1195273
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd27l; CD27LG; Tnfsf7; Tnlg8a
Summary: Predicted to enable cytokine activity and protease binding activity. Predicted to be involved in several processes, including B cell proliferation; T cell mediated immunity; and extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in Meckel's cartilage; hip; and skeleton. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 2.9), cerebellum adult (RPKM 2.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57452997..57456777, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57145997..57149777, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.
Title: The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity.
Title: cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction.
Title: Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction.
CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
Title: CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
that both human and mouse CD70-specific CAR T cells recognize primary CD70+ glioblastomas (GBM) tumors in vitro and mediate the regression of established GBM in xenograft and syngeneic models without illicit effect
Title: CD70, a novel target of CAR T-cell therapy for gliomas.
CD70 mitigates atherosclerosis at least in part by modulating macrophage function.
Title: CD70 limits atherosclerosis and promotes macrophage function.
these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses
Title: T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.
Title: Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Title: CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension.
Title: CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494165

NoName (e-PCR)
- UniSTS:489173

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD70 antigen

Names: CD27 ligand; CD27-L; Ki-24 antigen; tumor necrosis factor ligand 8a; tumor necrosis factor ligand superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011617.2 → NP_035747.1 CD70 antigen

See identical proteins and their annotated locations for NP_035747.1

Status: PROVISIONAL

Source sequence(s)

CT025692

Consensus CDS

CCDS28927.1

UniProtKB/Swiss-Prot

O55237

UniProtKB/TrEMBL

Q05A52

Related

ENSMUSP00000019633.8, ENSMUST00000019633.8

Conserved Domains (1) summary

cd00184
Location:60 → 191

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...