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Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus (house mouse) ]

Gene ID: 21936, updated on 5-Mar-2024

Summary

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Official Symbol
Tnfrsf18provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 18provided by MGI
Primary source
MGI:MGI:894675
See related
Ensembl:ENSMUSG00000041954 AllianceGenome:MGI:894675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AITR; Gitr
Summary
Predicted to enable tumor necrosis factor-activated receptor activity. Involved in positive regulation of cell adhesion. Located in external side of plasma membrane. Is expressed in genitourinary system; gut; heart ventricle; lung; and skin. Orthologous to human TNFRSF18 (TNF receptor superfamily member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.3), mammary gland adult (RPKM 14.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfrsf18 in Genome Data Viewer
Location:
4 E2; 4 87.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156110779..156113351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156026322..156028894)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 4 Neighboring gene tumor necrosis factor receptor superfamily, member 4 Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tubulin tyrosine ligase-like family, member 10 Neighboring gene predicted gene 13648 Neighboring gene microRNA 429

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC. Wiles KN, et al. Carcinogenesis, 2022 Oct 22. PMID 35880612, Free PMC Article
  2. Effects of protein-protein interface disruptors at the ligand of the glucocorticoid-induced tumor necrosis factor receptor-related gene (GITR). Platania CBM, et al. Biochem Pharmacol, 2020 Aug. PMID 32569630
  3. Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types. Zhu MMT, et al. Mod Pathol, 2020 Sep. PMID 32350416
  4. GITR differentially affects lung effector T cell subpopulations during influenza virus infection. Chu KL, et al. J Leukoc Biol, 2020 Jun. PMID 32125017
  5. Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression. Vashist N, et al. Front Immunol, 2018. PMID 29623077, Free PMC Article

See all (133) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC.
    Title: GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC.
  2. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
    Title: Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
  3. Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
    Title: Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR.
  4. T Cell-Intrinsic CX3CR1 Marks the Most Differentiated Effector CD4(+) T Cells, but Is Largely Dispensable for CD4(+) T Cell Responses during Chronic Viral Infection.
    Title: T Cell-Intrinsic CX3CR1 Marks the Most Differentiated Effector CD4(+) T Cells, but Is Largely Dispensable for CD4(+) T Cell Responses during Chronic Viral Infection.
  5. Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-kappaB signaling.
    Title: Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling.
  6. Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.
    Title: Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types.
  7. Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
    Title: Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
  8. GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.
    Title: GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.
  9. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
    Title: Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
  10. GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells.
    Title: GITR Agonism Triggers Antitumor Immune Responses through IL21-Expressing Follicular Helper T Cells.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 18
Names
glucocorticoid-induced TNFR-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009400.3 → NP_033426.1  tumor necrosis factor receptor superfamily member 18 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033426.1

    Status: VALIDATED

    Source sequence(s)
    AK020762, AK081878, AY157833
    Consensus CDS
    CCDS19056.1
    UniProtKB/Swiss-Prot
    O35714, Q9JKR1, Q9JKR2, Q9JKR3
    UniProtKB/TrEMBL
    Q540M6, Q8C4K3
    Related
    ENSMUSP00000099462.4, ENSMUST00000103173.10
    Conserved Domains (1) summary
    cd13417
    Location:43 → 168
    TNFRSF18; Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR)

  2. NM_021985.3 → NP_068820.1  tumor necrosis factor receptor superfamily member 18 isoform 2 precursor

    See identical proteins and their annotated locations for NP_068820.1

    Status: VALIDATED

    Source sequence(s)
    AK020762, AK081878, AY157833
    Consensus CDS
    CCDS19057.1
    UniProtKB/Swiss-Prot
    O35714
    Related
    ENSMUSP00000040035.8, ENSMUST00000040274.13
    Conserved Domains (2) summary
    cd00185
    Location:77 → 121
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:43 → 121
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156110779..156113351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35714.1 GenPept UniProtKB/Swiss-Prot:O35714

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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