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Akap11 A kinase anchor protein 11 [ Mus musculus (house mouse) ]

Gene ID: 219181, updated on 5-Mar-2024

Summary

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Official Symbol
Akap11provided by MGI
Official Full Name
A kinase anchor protein 11provided by MGI
Primary source
MGI:MGI:2684060
See related
Ensembl:ENSMUSG00000022016 AllianceGenome:MGI:2684060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm80; PRKA11; AKAP220; mKIAA0629; 6330501D17Rik
Summary
Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within cortical actin cytoskeleton organization; protein localization to endosome; and renal water homeostasis. Predicted to be located in several cellular components, including cytosol; nucleolus; and peroxisome. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 13.7), cortex adult (RPKM 12.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 41.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78729686..78774306, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (78492246..78536980, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78831878-78832061 Neighboring gene predicted gene, 18277 Neighboring gene STARR-positive B cell enhancer mm9_chr14:78848555-78848856 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37228 Neighboring gene STARR-positive B cell enhancer ABC_E5460 Neighboring gene STARR-seq mESC enhancer starr_37230 Neighboring gene diacylglycerol kinase, eta Neighboring gene predicted gene, 26251 Neighboring gene predicted gene, 30716

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Aryal S, et al. Cell Rep, 2023 May 30. PMID 37171958
  2. Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis. Gopalan J, et al. Elife, 2021 Jul 12. PMID 34250905, Free PMC Article
  3. Anchored protein kinase A recruitment of active Rac GTPase. Logue JS, et al. J Biol Chem, 2011 Jun 24. PMID 21460214, Free PMC Article
  4. Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients. Herzog LE, et al. Transl Psychiatry, 2023 Mar 13. PMID 36914641, Free PMC Article
  5. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Whiting JL, et al. Proc Natl Acad Sci U S A, 2016 Jul 26. PMID 27402760, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
    Title: Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
  2. Data suggest that membrane-proximal signaling complexes constrained by AKAP220 impact the actin barrier dynamics and AQP2 trafficking to ensure water homeostasis.
    Title: AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.
  3. IQGAP2 and AKAP220 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
    Title: Anchored protein kinase A recruitment of active Rac GTPase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to endosome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 11
Names
A kinase (PRKA) anchor protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164503.1 → NP_001157975.1  A-kinase anchor protein 11 isoform 1

    See identical proteins and their annotated locations for NP_001157975.1

    Status: VALIDATED

    Source sequence(s)
    AC161608, AK032821, AK158300, AK164604
    Consensus CDS
    CCDS49549.1
    UniProtKB/TrEMBL
    E9Q777
    Related
    ENSMUSP00000116015.3, ENSMUST00000123853.9
    Conserved Domains (1) summary
    cl14906
    Location:1808 → 1883
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  2. NM_001346784.1 → NP_001333713.1  A-kinase anchor protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161608
    Consensus CDS
    CCDS84155.1
    UniProtKB/TrEMBL
    E9Q777
    Conserved Domains (1) summary
    cl14906
    Location:1809 → 1884
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    78729686..78774306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158570.1 → XP_036014463.1  A-kinase anchor protein 11 isoform X3

    Conserved Domains (1) summary
    cl14906
    Location:1638 → 1855
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  2. XM_030247770.2 → XP_030103630.1  A-kinase anchor protein 11 isoform X1

    Conserved Domains (1) summary
    cl14906
    Location:1809 → 1884
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  3. XM_030247771.2 → XP_030103631.1  A-kinase anchor protein 11 isoform X2

    Conserved Domains (1) summary
    cl14906
    Location:1801 → 1876
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
Nucleotide Protein Strain
Heading Accession and Version

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