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Phf11a PHD finger protein 11A [ Mus musculus (house mouse) ]

Gene ID: 219131, updated on 11-Apr-2024

Summary

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Official Symbol
Phf11aprovided by MGI
Official Full Name
PHD finger protein 11Aprovided by MGI
Primary source
MGI:MGI:1918441
See related
Ensembl:ENSMUSG00000044703 AllianceGenome:MGI:1918441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf11; Phf11l; 4933417L10Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within regulation of immune response. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PHF11 (PHD finger protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 2.6), mammary gland adult (RPKM 2.4) and 21 other tissues See more
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Genomic context

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Location:
14 C3; 14 31.48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (59514362..59534972, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (59276913..59297564, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36837 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 Neighboring gene PHD finger protein 11 Neighboring gene STARR-positive B cell enhancer mm9_chr14:59916339-59916640 Neighboring gene PHD finger protein 11B Neighboring gene STARR-positive B cell enhancer ABC_E11570 Neighboring gene STARR-seq mESC enhancer starr_36838 Neighboring gene PHD finger protein 11D Neighboring gene STARR-seq mESC enhancer starr_36839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant. Zhang Y, et al. Mamm Genome, 2014 Dec. PMID 25091723, Free PMC Article
  2. PHF11 promotes DSB resection, ATR signaling, and HR. Gong Y, et al. Genes Dev, 2017 Jan 1. PMID 28115467, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PHD finger protein 11A
Names
PHD finger protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172603.3 → NP_766191.1  PHD finger protein 11A

    See identical proteins and their annotated locations for NP_766191.1

    Status: VALIDATED

    Source sequence(s)
    BY162942, EU155109
    Consensus CDS
    CCDS27169.1
    UniProtKB/Swiss-Prot
    Q8BVM9
    Related
    ENSMUSP00000053146.5, ENSMUST00000062307.5
    Conserved Domains (1) summary
    cl22851
    Location:28 → 142
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    59514362..59534972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315970.3 → XP_017171459.1  PHD finger protein 11A isoform X2

    Conserved Domains (1) summary
    cl22851
    Location:28 → 142
    PHD_SF; PHD finger superfamily

  2. XM_011245023.4 → XP_011243325.1  PHD finger protein 11A isoform X1

    Conserved Domains (1) summary
    cl22851
    Location:6 → 120
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVM9.1 GenPept UniProtKB/Swiss-Prot:Q8BVM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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