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Ska3 spindle and kinetochore associated complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 219114, updated on 5-Mar-2024

Summary

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Official Symbol
Ska3provided by MGI
Official Full Name
spindle and kinetochore associated complex subunit 3provided by MGI
Primary source
MGI:MGI:3041235
See related
Ensembl:ENSMUSG00000021965 AllianceGenome:MGI:3041235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F630043A04Rik
Summary
Predicted to be involved in chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within cell division. Predicted to be located in cytosol; kinetochore; and microtubule cytoskeleton. Predicted to be part of outer kinetochore. Predicted to be active in spindle microtubule. Is expressed in brain; heart ventricle; lung; and vertebral axis musculature. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.5), liver E14 (RPKM 5.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 30.51 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58044016..58063748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57806558..57826291, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 52140 Neighboring gene STARR-seq mESC enhancer starr_36815 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene predicted gene, 22738 Neighboring gene zinc finger, DHHC domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SKA3, negatively regulated by miR-128-3p, promotes the progression of non-small-cell lung cancer. Xie L, et al. Per Med, 2022 May. PMID 34533066
  2. Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. Theis M, et al. EMBO J, 2009 May 20. PMID 19387489, Free PMC Article
  3. Localization and function of the Ska complex during mouse oocyte meiotic maturation. Zhang QH, et al. Cell Cycle, 2012 Mar 1. PMID 22336914
  4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
  5. Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis. Gao W, et al. Cell Death Dis, 2020 Oct 26. PMID 33106477, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindle and kinetochore-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418937.1 → NP_001405866.1  spindle and kinetochore-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119813

  2. NM_001418938.1 → NP_001405867.1  spindle and kinetochore-associated protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119813

  3. NM_001418939.1 → NP_001405868.1  spindle and kinetochore-associated protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119813

  4. NM_198605.4 → NP_941007.1  spindle and kinetochore-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_941007.1

    Status: VALIDATED

    Source sequence(s)
    AC119813
    Consensus CDS
    CCDS27160.1
    UniProtKB/Swiss-Prot
    Q149T5, Q149T6, Q8C263
    Related
    ENSMUSP00000022536.3, ENSMUST00000022536.3
    Conserved Domains (1) summary
    cd12957
    Location:3 → 101
    SKA3_N; Spindle and kinetochore-associated protein 3, N-terminal domain

RNA

  1. NR_184859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119813

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    58044016..58063748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938385.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C263.1 GenPept UniProtKB/Swiss-Prot:Q8C263

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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