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Haus4 HAUS augmin-like complex, subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 219072, updated on 30-Apr-2024

Summary

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Official Symbol
Haus4provided by MGI
Official Full Name
HAUS augmin-like complex, subunit 4provided by MGI
Primary source
MGI:MGI:1261794
See related
Ensembl:ENSMUSG00000022177 AllianceGenome:MGI:1261794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14Ertd500e; 9430093H08Rik
Summary
Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Is expressed in cartilage; musculoskeletal system; and sensory organ. Orthologous to human HAUS4 (HAUS augmin like complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 20.6), genital fat pad adult (RPKM 10.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C2; 14 27.83 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54779242..54792446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54541785..54554989, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA arginine 6 (anticodon ACG) Neighboring gene predicted gene, 53858 Neighboring gene STARR-seq mESC enhancer starr_36740 Neighboring gene ajuba LIM protein Neighboring gene STARR-seq mESC enhancer starr_36741 Neighboring gene STARR-positive B cell enhancer ABC_E7313 Neighboring gene U6 small nuclear RNA, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145462.2 → NP_663437.2  HAUS augmin-like complex subunit 4

    See identical proteins and their annotated locations for NP_663437.2

    Status: VALIDATED

    Source sequence(s)
    AI642699, AK079852, BB855694
    Consensus CDS
    CCDS27092.1
    UniProtKB/Swiss-Prot
    Q8BFT2, Q99KI1
    Related
    ENSMUSP00000022784.9, ENSMUST00000022784.9
    Conserved Domains (1) summary
    pfam14735
    Location:126 → 360
    HAUS4; HAUS augmin-like complex subunit 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54779242..54792446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247756.1 → XP_030103616.1  HAUS augmin-like complex subunit 4 isoform X2

    Conserved Domains (1) summary
    pfam14735
    Location:1 → 210
    HAUS4; HAUS augmin-like complex subunit 4

  2. XM_006518845.5 → XP_006518908.1  HAUS augmin-like complex subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006518908.1

    UniProtKB/Swiss-Prot
    Q8BFT2, Q99KI1
    Conserved Domains (1) summary
    pfam14735
    Location:126 → 360
    HAUS4; HAUS augmin-like complex subunit 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFT2.1 GenPept UniProtKB/Swiss-Prot:Q8BFT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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