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Wdhd1 WD repeat and HMG-box DNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 218973, updated on 5-Mar-2024

Summary

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Official Symbol
Wdhd1provided by MGI
Official Full Name
WD repeat and HMG-box DNA binding protein 1provided by MGI
Primary source
MGI:MGI:2443514
See related
Ensembl:ENSMUSG00000037572 AllianceGenome:MGI:2443514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AND-1; A630092E18; D630024B06Rik
Summary
Enables RNA binding activity; RNA polymerase binding activity; and chromatin binding activity. Acts upstream of or within RNA processing; pericentric heterochromatin organization; and regulation of chromosome organization. Located in chromosome, centromeric region. Is expressed in brain ventricular layer; inferior colliculus; submandibular gland primordium; and thymus primordium. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 17.1), liver E14.5 (RPKM 13.7) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C1; 14 24.6 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47478401..47514352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47240944..47276861, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52169 Neighboring gene STARR-positive B cell enhancer ABC_E4106 Neighboring gene GTP cyclohydrolase 1 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:47842732-47842946 Neighboring gene STARR-seq mESC enhancer starr_36567 Neighboring gene predicted gene, 24378 Neighboring gene suppressor of cytokine signaling 4 Neighboring gene STARR-seq mESC enhancer starr_36570 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1-like Neighboring gene predicted gene, 35078

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wdhd1 is essential for early mouse embryogenesis. Fan HH, et al. Biochim Biophys Acta Mol Cell Res, 2021 May. PMID 33716172
  2. Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis. Prakash Yadav R, et al. Reproduction, 2023 Jan 1. PMID 36194437, Free PMC Article
  3. WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. Hsieh CL, et al. Nucleic Acids Res, 2011 May. PMID 21266480, Free PMC Article
  4. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article
  5. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
    Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
  2. Wdhd1 is essential for early mouse embryogenesis.
    Title: Wdhd1 is essential for early mouse embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within RNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pericentric heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD repeat and HMG-box DNA-binding protein 1
Names
acidic nucleoplasmic DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360532.1 → NP_001347461.1  WD repeat and HMG-box DNA-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156016, AK036390, AK052690, AK160777, BE980284, BQ748927, BY210513, CF163129
    Consensus CDS
    CCDS88642.1
    UniProtKB/Swiss-Prot
    P59328, Q6P408
    UniProtKB/TrEMBL
    A0A2K6EDP7
    Related
    ENSMUSP00000141182.3, ENSMUST00000187531.8
    Conserved Domains (5) summary
    smart00398
    Location:1006 → 1063
    HMG; high mobility group
    COG5648
    Location:949 → 1061
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00200
    Location:10 → 289
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:21 → 54
    7WD40; WD40 repeat [structural motif]
    pfam12341
    Location:425 → 707
    Mcl1_mid; Minichromosome loss protein, Mcl1, middle region

  2. NM_172598.3 → NP_766186.2  WD repeat and HMG-box DNA-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_766186.2

    Status: VALIDATED

    Source sequence(s)
    AC156016, BC063740
    Consensus CDS
    CCDS88641.1
    UniProtKB/Swiss-Prot
    P59328, Q6P408
    UniProtKB/TrEMBL
    A0A0R4J1F8
    Related
    ENSMUSP00000107422.2, ENSMUST00000111792.9
    Conserved Domains (5) summary
    smart00398
    Location:969 → 1026
    HMG; high mobility group
    COG2319
    Location:1 → 303
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:10 → 289
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12341
    Location:388 → 670
    Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
    sd00039
    Location:21 → 54
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    47478401..47514352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245012.4 → XP_011243314.1  WD repeat and HMG-box DNA-binding protein 1 isoform X1

    Related
    ENSMUSP00000107420.2, ENSMUST00000111790.2
    Conserved Domains (3) summary
    cd00200
    Location:10 → 289
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:21 → 54
    7WD40; WD40 repeat [structural motif]
    pfam12341
    Location:424 → 589
    Mcl1_mid; Minichromosome loss protein, Mcl1, middle region

RNA

  1. XR_001781110.3 RNA Sequence

  2. XR_004938381.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59328.2 GenPept UniProtKB/Swiss-Prot:P59328

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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