U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sema3g sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [ Mus musculus (house mouse) ]

Gene ID: 218877, updated on 16-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Sema3gprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gprovided by MGI
Primary source
MGI:MGI:3041242
See related
Ensembl:ENSMUSG00000021904 AllianceGenome:MGI:3041242
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables signaling receptor binding activity. Involved in negative regulation of axon extension. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in brain and renal cortex. Orthologous to human SEMA3G (semaphorin 3G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 46.9), kidney adult (RPKM 14.8) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14 B; 14 19.09 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30939830..30952309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31217873..31230352)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nischarin Neighboring gene troponin C, cardiac/slow skeletal Neighboring gene STARR-positive B cell enhancer ABC_E7302 Neighboring gene PHD finger protein 7 Neighboring gene Brca1 associated protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4. Tan C, et al. Neuron, 2019 Mar 6. PMID 30685224
  2. Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors. Hyun J, et al. J Physiol, 2022 Feb. PMID 34921404, Free PMC Article
  3. Reciprocal modulation of Ca(v) 2.3 voltage-gated calcium channels by copper(II) ions and kainic acid. Neumaier F, et al. J Neurochem, 2018 Nov. PMID 29972687
  4. Identification and characterization of a novel member of murine semaphorin family. Taniguchi M, et al. Genes Cells, 2005 Aug. PMID 16098142
  5. Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling. Chen DY, et al. J Clin Invest, 2021 Feb 15. PMID 33586674, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors.
    Title: Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors.
  2. Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating beta-catenin-dependent vascular remodeling.
    Title: Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling.
  3. Loss of Sema3G in the vascular endothelium results in behavioral and memory deficits. Sema3G regulates synaptic structure and function via the neuropilin-2/PlexinA4 receptor
    Title: Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4.
  4. Results indicate that Sema3G protein is secreted by podocytes and protects them from inflammatory kidney diseases and diabetic nephropathy.
    Title: A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.
  5. Sema3G induces cell collapse in an Nrp2/PlexinD1-dependent manner.
    Title: Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.
  6. Identify Sema3G as a primarily endothelial cell-expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners.
    Title: Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.
  7. In adulthood, Sema3G is mainly expressed in the lung and kidney, and a little in the brain. We also found that Sema3G binds Neuropilin-2, but not Neuropilin-1, and induces the repulsion of sympathetic axons.
    Title: Identification and characterization of a novel member of murine semaphorin family.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
semaphorin-3G
Names
Semaphorin 3G

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025379.1 → NP_001020550.1  semaphorin-3G precursor

    See identical proteins and their annotated locations for NP_001020550.1

    Status: PROVISIONAL

    Source sequence(s)
    AB127607
    Consensus CDS
    CCDS26908.1
    UniProtKB/Swiss-Prot
    Q3UVA7, Q4LFA9
    Related
    ENSMUSP00000087643.3, ENSMUST00000090180.4
    Conserved Domains (3) summary
    cd05871
    Location:591 → 676
    Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
    smart00423
    Location:521 → 567
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl15693
    Location:49 → 522
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30939830..30952309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518821.4 → XP_006518884.1  semaphorin-3G isoform X1

    Conserved Domains (3) summary
    cd05871
    Location:554 → 639
    Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin
    smart00423
    Location:484 → 530
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl15693
    Location:12 → 485
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4LFA9.1 GenPept UniProtKB/Swiss-Prot:Q4LFA9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous