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Tasor transcription activation suppressor [ Mus musculus (house mouse) ]

Gene ID: 218850, updated on 3-Apr-2024

Summary

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Official Symbol
Tasorprovided by MGI
Official Full Name
transcription activation suppressorprovided by MGI
Primary source
MGI:MGI:1921694
See related
Ensembl:ENSMUSG00000040651 AllianceGenome:MGI:1921694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam208a; MommeD6; D14Abb1e; 4732418E12; 4933409E02Rik
Summary
Predicted to enable chromatin binding activity. Involved in anterior/posterior axis specification, embryo and mesodermal to mesenchymal transition involved in gastrulation. Acts upstream of or within in utero embryonic development and mitotic spindle assembly. Predicted to be located in chromosome and nucleus. Predicted to be active in heterochromatin and nucleoplasm. Is expressed in several structures, including brain; ovary stratum granulosum; and seminiferous tubule. Orthologous to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.4), CNS E18 (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 16.51 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (27150759..27205512)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (27423674..27483555)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene STARR-seq mESC enhancer starr_36271 Neighboring gene STARR-positive B cell enhancer ABC_E1891 Neighboring gene predicted gene, 52096 Neighboring gene predicted gene, 34702 Neighboring gene STARR-seq mESC enhancer starr_36272 Neighboring gene STARR-seq mESC enhancer starr_36273 Neighboring gene STARR-positive B cell enhancer ABC_E8897 Neighboring gene STARR-seq mESC enhancer starr_36274 Neighboring gene coiled-coil domain containing 66 Neighboring gene STARR-seq mESC enhancer starr_36275 Neighboring gene predicted gene, 25697 Neighboring gene predicted gene 7604

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Harten SK, et al. Mamm Genome, 2014 Aug. PMID 24781204, Free PMC Article
  2. A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Ashe A, et al. Genome Biol, 2008. PMID 19099580, Free PMC Article
  3. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Blewitt ME, et al. Proc Natl Acad Sci U S A, 2005 May 24. PMID 15890782, Free PMC Article
  4. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
  5. The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Bhargava S, et al. Sci Rep, 2017 Aug 24. PMID 28839193, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biological_process ND
No biological Data available
more info
  
involved_in mesodermal to mesenchymal transition involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to heterochromatin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein TASOR
Names
family with sequence similarity 208, member A
protein FAM208A
retinoblastoma-associated protein 140
transgene activation suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114879.3 → NP_001108351.1  protein TASOR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787
    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Conserved Domains (1) summary
    pfam12509
    Location:153 → 314
    DUF3715; Protein of unknown function (DUF3715)

  2. NM_001404930.1 → NP_001391859.1  protein TASOR isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787

  3. NM_028945.3 → NP_083221.1  protein TASOR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154327, CT485787
    Consensus CDS
    CCDS49432.1
    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Related
    ENSMUSP00000022450.5, ENSMUST00000022450.6
    Conserved Domains (1) summary
    pfam12509
    Location:153 → 314
    DUF3715; Protein of unknown function (DUF3715)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    27150759..27205512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518820.5 → XP_006518883.1  protein TASOR isoform X1

    UniProtKB/Swiss-Prot
    E9PUH2, Q69ZR9, Q9CUD3
    Conserved Domains (1) summary
    pfam12509
    Location:161 → 314
    DUF3715; Protein of unknown function (DUF3715)

RNA

  1. XR_383159.5 RNA Sequence

  2. XR_383158.5 RNA Sequence

  3. XR_004938380.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZR9.2 GenPept UniProtKB/Swiss-Prot:Q69ZR9

Gene LinkOut

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