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Sec24c SEC24 homolog C, COPII coat complex component [ Mus musculus (house mouse) ]

Gene ID: 218811, updated on 21-Apr-2024

Summary

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Official Symbol
Sec24cprovided by MGI
Official Full Name
SEC24 homolog C, COPII coat complex componentprovided by MGI
Primary source
MGI:MGI:1919746
See related
Ensembl:ENSMUSG00000039367 AllianceGenome:MGI:1919746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0079; 2610204K03Rik
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in embryo and future spinal cord. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 52.7), large intestine adult (RPKM 44.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20722709..20744920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20674285..20694852)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myozenin 1 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene synaptopodin 2-like Neighboring gene STARR-seq mESC enhancer starr_36115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21501696-21501849 Neighboring gene microRNA 6946 Neighboring gene fucosyltransferase 11 Neighboring gene predicted gene, 25328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine SEC24D can substitute functionally for SEC24C during embryonic development. Adams EJ, et al. Sci Rep, 2021 Oct 26. PMID 34702932, Free PMC Article
  2. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. Sucic S, et al. J Biol Chem, 2011 May 6. PMID 21454670, Free PMC Article
  3. Mammalian COPII coat component SEC24C is required for embryonic development in mice. Adams EJ, et al. J Biol Chem, 2014 Jul 25. PMID 24876386, Free PMC Article
  4. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Chanrion B, et al. Proc Natl Acad Sci U S A, 2007 May 8. PMID 17452640, Free PMC Article
  5. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Murine SEC24D can substitute functionally for SEC24C during embryonic development.
    Title: Murine SEC24D can substitute functionally for SEC24C during embryonic development.
  2. These data suggest that SEC24C is a major cargo adapter for COPII-dependent transport in postmitotic neurons in developing and adult brains and that its functions overlap at least partially with those of SEC24D in mammals.
    Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
  3. Thus, SEC24C is required in early mammalian development but is dispensable in a number of tissues, likely as a result of compensation by other Sec24 paralogs.
    Title: Mammalian COPII coat component SEC24C is required for embryonic development in mice.
  4. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
    Title: The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein transport protein Sec24C
Names
Sec24 related gene family, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168273.1 → NP_001161745.1  protein transport protein Sec24C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment and contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK036519, AK122199
    Consensus CDS
    CCDS88586.1
    UniProtKB/TrEMBL
    A0A286YDI8, Q80U83
    Related
    ENSMUSP00000153434.2, ENSMUST00000223751.2
    Conserved Domains (7) summary
    COG5028
    Location:80 → 1016
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:425 → 684
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:890 → 962
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:348 → 385
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:773 → 869
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:674 → 757
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam12764
    Location:11 → 105
    Gly-rich_Ago1; Glycine-rich region of argonaut

  2. NM_172596.2 → NP_766184.2  protein transport protein Sec24C isoform 1

    See identical proteins and their annotated locations for NP_766184.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK036519, AK122199
    Consensus CDS
    CCDS26850.1
    UniProtKB/TrEMBL
    G3X972, Q8CGF4
    Related
    ENSMUSP00000045955.9, ENSMUST00000048657.10
    Conserved Domains (2) summary
    PHA03377
    Location:21 → 224
    PHA03377; EBNA-3C; Provisional
    COG5028
    Location:181 → 1092
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20722709..20744920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518813.2 → XP_006518876.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518876.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  2. XM_006518817.2 → XP_006518880.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1115
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  3. XM_036158551.1 → XP_036014444.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1115
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  4. XM_030247745.2 → XP_030103605.1  protein transport protein Sec24C isoform X4

    UniProtKB/TrEMBL
    G3X972, Q8CGF4
    Conserved Domains (2) summary
    PHA03377
    Location:21 → 224
    PHA03377; EBNA-3C; Provisional
    COG5028
    Location:181 → 1092
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

  5. XM_006518816.3 → XP_006518879.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518879.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  6. XM_006518815.3 → XP_006518878.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006518878.1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  7. XM_030247743.2 → XP_030103603.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  8. XM_036158550.1 → XP_036014443.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1117
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  9. XM_036158552.1 → XP_036014445.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  10. XM_006518818.3 → XP_006518881.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein

  11. XM_030247744.2 → XP_030103604.1  protein transport protein Sec24C isoform X3

    UniProtKB/TrEMBL
    Q8CGF4
    Conserved Domains (2) summary
    COG5028
    Location:181 → 1094
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    pfam15449
    Location:12 → 235
    Retinal; Retinal protein
Nucleotide Protein Strain
Heading Accession and Version

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