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Lrrc3b leucine rich repeat containing 3B [ Mus musculus (house mouse) ]

Gene ID: 218763, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc3bprovided by MGI
Official Full Name
leucine rich repeat containing 3Bprovided by MGI
Primary source
MGI:MGI:2384996
See related
Ensembl:ENSMUSG00000045201 AllianceGenome:MGI:2384996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LRP15
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRC3B (leucine rich repeat containing 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 9.9), cerebellum adult (RPKM 6.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 7.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7030776..7112248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (15357515..15438987, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:16602478-16602631 Neighboring gene predicted gene, 31804 Neighboring gene STARR-seq mESC enhancer starr_36010 Neighboring gene STARR-seq mESC enhancer starr_36009 Neighboring gene STARR-seq mESC enhancer starr_36008 Neighboring gene STARR-seq mESC enhancer starr_36007 Neighboring gene STARR-seq mESC enhancer starr_36006 Neighboring gene RIKEN cDNA B230110C06 gene Neighboring gene STARR-seq mESC enhancer starr_36005 Neighboring gene STARR-seq mESC enhancer starr_36004 Neighboring gene predicted gene, 31658 Neighboring gene predicted gene, 31577 Neighboring gene STARR-seq mESC enhancer starr_36003 Neighboring gene STARR-seq mESC enhancer starr_36002 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:15916488-15916671 Neighboring gene predicted gene, 31517

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Odor-evoked gene regulation and visualization in olfactory receptor neurons. Bennett MK, et al. Mol Cell Neurosci, 2010 Apr. PMID 20080187, Free PMC Article
  2. Activity-dependent genes in mouse olfactory sensory neurons. Fischl AM, et al. Chem Senses, 2014 Jun. PMID 24692514, Free PMC Article
  3. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
  4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC30505

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 3B
Names
leucine-rich repeat protein 15
leucine-rich repeat protein LRP15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425741.1 → NP_001412670.1  leucine-rich repeat-containing protein 3B precursor

    Status: VALIDATED

    Source sequence(s)
    AC117656, AC158537
    UniProtKB/Swiss-Prot
    Q8VCH9
    UniProtKB/TrEMBL
    Q543Z7

  2. NM_001425742.1 → NP_001412671.1  leucine-rich repeat-containing protein 3B precursor

    Status: VALIDATED

    Source sequence(s)
    AC117656, AC158537
    UniProtKB/Swiss-Prot
    Q8VCH9
    UniProtKB/TrEMBL
    Q543Z7

  3. NM_146052.5 → NP_666164.1  leucine-rich repeat-containing protein 3B precursor

    See identical proteins and their annotated locations for NP_666164.1

    Status: VALIDATED

    Source sequence(s)
    AC117656, AC158537
    Consensus CDS
    CCDS26829.1
    UniProtKB/Swiss-Prot
    Q8VCH9
    UniProtKB/TrEMBL
    Q543Z7
    Related
    ENSMUSP00000059463.5, ENSMUST00000055211.6
    Conserved Domains (3) summary
    smart00013
    Location:33 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:66 → 89
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69 → 125
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    7030776..7112248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518006.3 → XP_006518069.1  leucine-rich repeat-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006518069.1

    UniProtKB/Swiss-Prot
    Q8VCH9
    UniProtKB/TrEMBL
    Q543Z7
    Related
    ENSMUSP00000153616.2, ENSMUST00000223700.2
    Conserved Domains (3) summary
    smart00013
    Location:33 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:66 → 89
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69 → 125
    LRR_8; Leucine rich repeat

  2. XM_006518005.3 → XP_006518068.1  leucine-rich repeat-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006518068.1

    UniProtKB/Swiss-Prot
    Q8VCH9
    UniProtKB/TrEMBL
    Q543Z7
    Related
    ENSMUSP00000128624.2, ENSMUST00000163937.3
    Conserved Domains (3) summary
    smart00013
    Location:33 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:66 → 89
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69 → 125
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCH9.1 GenPept UniProtKB/Swiss-Prot:Q8VCH9

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