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Mier3 MIER family member 3 [ Mus musculus (house mouse) ]

Gene ID: 218613, updated on 5-Mar-2024

Summary

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Official Symbol
Mier3provided by MGI
Official Full Name
MIER family member 3provided by MGI
Primary source
MGI:MGI:2442317
See related
Ensembl:ENSMUSG00000032727 AllianceGenome:MGI:2442317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730509D14; D130064H19Rik
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D2.2; 13 63.36 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111822607..111855130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111686073..111718596)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35655 Neighboring gene STARR-seq mESC enhancer starr_35658 Neighboring gene predicted gene 15290 Neighboring gene STARR-seq mESC enhancer starr_35661 Neighboring gene STARR-seq mESC enhancer starr_35662 Neighboring gene predicted gene 15286 Neighboring gene STARR-positive B cell enhancer ABC_E10815 Neighboring gene STARR-positive B cell enhancer ABC_E7283 Neighboring gene STARR-seq mESC enhancer starr_35666 Neighboring gene STARR-positive B cell enhancer ABC_E386 Neighboring gene SET domain containing 9, pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7284 Neighboring gene STARR-positive B cell enhancer mm9_chr13:112587011-112587312 Neighboring gene STARR-positive B cell enhancer ABC_E1889 Neighboring gene STARR-positive B cell enhancer ABC_E4094 Neighboring gene predicted gene 15327

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC117989

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 3
Names
mesoderm induction early response 1, family member 3
mi-er3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172593.3 → NP_766181.2  mesoderm induction early response protein 3

    See identical proteins and their annotated locations for NP_766181.2

    Status: VALIDATED

    Source sequence(s)
    AC118704, AK083929, AK147427
    Consensus CDS
    CCDS26770.2
    UniProtKB/Swiss-Prot
    Q3SYJ7, Q3UGR9, Q3UHF3, Q8BND7, Q8BSS0
    UniProtKB/TrEMBL
    F7BFR0
    Related
    ENSMUSP00000104895.3, ENSMUST00000109272.9
    Conserved Domains (3) summary
    smart00717
    Location:281 → 328
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:283 → 327
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:176 → 225
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    111822607..111855130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517618.3 → XP_006517681.1  mesoderm induction early response protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006517681.1

    UniProtKB/TrEMBL
    B9EHL0, F7BFR0
    Conserved Domains (2) summary
    cd11661
    Location:256 → 300
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:149 → 198
    ELM2; ELM2 domain

  2. XM_030247238.2 → XP_030103098.1  mesoderm induction early response protein 3 isoform X3

    UniProtKB/TrEMBL
    F7BFR0
    Related
    ENSMUSP00000104894.3, ENSMUST00000109271.3
    Conserved Domains (2) summary
    cd11661
    Location:282 → 326
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:176 → 225
    ELM2; ELM2 domain

  3. XM_006517615.3 → XP_006517678.1  mesoderm induction early response protein 3 isoform X1

    UniProtKB/TrEMBL
    F7BFR0
    Conserved Domains (2) summary
    cd11661
    Location:329 → 373
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:222 → 271
    ELM2; ELM2 domain

  4. XM_006517616.3 → XP_006517679.1  mesoderm induction early response protein 3 isoform X2

    UniProtKB/TrEMBL
    F7BFR0
    Conserved Domains (2) summary
    cd11661
    Location:328 → 372
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:222 → 271
    ELM2; ELM2 domain

  5. XM_036158025.1 → XP_036013918.1  mesoderm induction early response protein 3 isoform X4

    UniProtKB/TrEMBL
    B9EHL0, F7BFR0
    Conserved Domains (2) summary
    cd11661
    Location:256 → 300
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:149 → 198
    ELM2; ELM2 domain

  6. XM_006517617.1 → XP_006517680.1  mesoderm induction early response protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006517680.1

    UniProtKB/TrEMBL
    F7BFR0
    Related
    ENSMUSP00000036809.5, ENSMUST00000047412.11
    Conserved Domains (2) summary
    cd11661
    Location:255 → 299
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:149 → 198
    ELM2; ELM2 domain

RNA

  1. XR_382733.3 RNA Sequence

    Related
    ENSMUST00000137268.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHF3.2 GenPept UniProtKB/Swiss-Prot:Q3UHF3

Gene LinkOut

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