U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Timm17a translocase of inner mitochondrial membrane 17a [ Mus musculus (house mouse) ]

Gene ID: 21854, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Timm17aprovided by MGI
Official Full Name
translocase of inner mitochondrial membrane 17aprovided by MGI
Primary source
MGI:MGI:1343131
See related
Ensembl:ENSMUSG00000062580 AllianceGenome:MGI:1343131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim17a; mTim17a
Summary
Predicted to enable enzyme binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in positive regulation of protein processing and protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in 4-cell stage embryo. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 42.4), placenta adult (RPKM 34.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 E4; 1 58.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135229273..135241475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135301535..135313737, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase (aminopeptidase B) Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137210226-137210413 Neighboring gene predicted gene, 41956 Neighboring gene leiomodin 1 (smooth muscle) Neighboring gene STARR-seq mESC enhancer starr_02362 Neighboring gene STARR-seq mESC enhancer starr_02364

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Ishihara N, et al. Nat Cell Biol, 2009 Aug. PMID 19578372
  2. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial import inner membrane translocase subunit Tim17-A
Names
inner membrane preprotein translocase Tim17a
translocator of inner mitochondrial membrane 17 kDa, a
translocator of inner mitochondrial membrane 17a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360857.1 → NP_001347786.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC130277
    Conserved Domains (1) summary
    cl02381
    Location:1 → 149
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_001360858.1 → NP_001347787.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC130277
    Conserved Domains (1) summary
    cl02381
    Location:1 → 92
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  3. NM_011590.2 → NP_035720.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform 2

    See identical proteins and their annotated locations for NP_035720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK003129
    Consensus CDS
    CCDS15318.1
    UniProtKB/Swiss-Prot
    Q9Z0V8
    UniProtKB/TrEMBL
    Q545U2
    Related
    ENSMUSP00000079883.4, ENSMUST00000081104.10
    Conserved Domains (1) summary
    TIGR00980
    Location:1 → 171
    3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135229273..135241475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001360856.1: Suppressed sequence

    Description
    NM_001360856.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0V8.1 GenPept UniProtKB/Swiss-Prot:Q9Z0V8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous