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Mrps27 mitochondrial ribosomal protein S27 [ Mus musculus (house mouse) ]

Gene ID: 218506, updated on 5-Mar-2024

Summary

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Official Symbol
Mrps27provided by MGI
Official Full Name
mitochondrial ribosomal protein S27provided by MGI
Primary source
MGI:MGI:1919064
See related
Ensembl:ENSMUSG00000041632 AllianceGenome:MGI:1919064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610028H14Rik
Summary
Predicted to enable mitochondrial ribosome binding activity; rRNA binding activity; and tRNA binding activity. Predicted to be involved in cell population proliferation and positive regulation of mitochondrial translation. Predicted to act upstream of or within regulation of translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; extraembryonic component; gonad; nervous system; and sensory organ. Orthologous to human MRPS27 (mitochondrial ribosomal protein S27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 13.1), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 52.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (99481275..99552070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (99344767..99415562)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 366 Neighboring gene STARR-seq mESC enhancer starr_35452 Neighboring gene STARR-seq mESC enhancer starr_35453 Neighboring gene STARR-seq mESC enhancer starr_35456 Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene STARR-positive B cell enhancer mm9_chr13:100123104-100123405 Neighboring gene RIKEN cDNA 6430562O15 gene Neighboring gene microtubule-associated protein 1B Neighboring gene STARR-seq mESC enhancer starr_35459 Neighboring gene predicted gene, 26559

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes. Shi Z, et al. FASEB J, 2019 Nov. PMID 31487196
  2. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, et al. Nat Commun, 2016 Jun 20. PMID 27319982, Free PMC Article
  3. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
  4. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
  5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS27
Names
28S ribosomal protein S27, mitochondrial
MRP-S27
S27mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173757.3 → NP_776118.2  small ribosomal subunit protein mS27

    See identical proteins and their annotated locations for NP_776118.2

    Status: VALIDATED

    Source sequence(s)
    AA461997, AK076008, AK087686
    Consensus CDS
    CCDS26722.1
    UniProtKB/Swiss-Prot
    E9QKZ5, Q8BK72
    Related
    ENSMUSP00000062326.6, ENSMUST00000052249.7
    Conserved Domains (2) summary
    sd00004
    Location:111 → 135
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:1 → 412
    MRP-S27; Mitochondrial 28S ribosomal protein S27

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    99481275..99552070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517602.1 → XP_006517665.1  small ribosomal subunit protein mS27 isoform X1

    Conserved Domains (2) summary
    sd00004
    Location:182 → 212
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:1 → 453
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  2. XM_017315495.2 → XP_017170984.1  small ribosomal subunit protein mS27 isoform X2

    Conserved Domains (2) summary
    sd00004
    Location:112 → 142
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:25 → 383
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  3. XM_017315496.2 → XP_017170985.1  small ribosomal subunit protein mS27 isoform X3

    Conserved Domains (2) summary
    sd00004
    Location:41 → 65
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:25 → 342
    MRP-S27; Mitochondrial 28S ribosomal protein S27

  4. XM_036158019.1 → XP_036013912.1  small ribosomal subunit protein mS27 isoform X4

    UniProtKB/TrEMBL
    Q80ZI4
    Conserved Domains (2) summary
    sd00004
    Location:33 → 63
    PPR; PPR repeat [structural motif]
    pfam10037
    Location:25 → 304
    MRP-S27; Mitochondrial 28S ribosomal protein S27
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK72.2 GenPept UniProtKB/Swiss-Prot:Q8BK72

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