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Gcnt4 glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase) [ Mus musculus (house mouse) ]

Gene ID: 218476, updated on 17-Mar-2024

Summary

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Official Symbol
Gcnt4provided by MGI
Official Full Name
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)provided by MGI
Primary source
MGI:MGI:2684919
See related
Ensembl:ENSMUSG00000091387 AllianceGenome:MGI:2684919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm73; Gm279; C2gnt3
Summary
Predicted to enable acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including inter-male aggressive behavior; kidney morphogenesis; and thyroid hormone metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Orthologous to human GCNT4 (glucosaminyl (N-acetyl) transferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 8.0), large intestine adult (RPKM 4.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Gcnt4 in Genome Data Viewer
Location:
13 D1; 13 50.66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97060852..97087422)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96924344..96950914)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33171 Neighboring gene ankyrin repeat domain 31 Neighboring gene predicted gene, 57606 Neighboring gene STARR-seq mESC enhancer starr_35351 Neighboring gene STARR-seq mESC enhancer starr_35353 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97735001-97735184 Neighboring gene predicted gene, 41027 Neighboring gene RIKEN cDNA 1700029F12 gene Neighboring gene predicted gene, 41028

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147. Fan J, et al. Glycoconj J, 2012 Aug. PMID 22736280
  2. High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Ismail MN, et al. Glycobiology, 2011 Jan. PMID 20855471, Free PMC Article
  3. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. Kidder D, et al. J Immunol, 2013 Mar 15. PMID 23408841, Free PMC Article
  4. Requirement for core 2 O-glycans for optimal resistance to helminth infection. Mullaly SC, et al. PLoS One, 2013. PMID 23555902, Free PMC Article
  5. Glycosyltransferase function in core 2-type protein O glycosylation. Stone EL, et al. Mol Cell Biol, 2009 Jul. PMID 19349303, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.
    Title: CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.
  2. N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
    Title: N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inter-male aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
Names
core 2 beta-1,6-N-acetylglucosaminyltransferase 3
core 2-branching enzyme 3
core2-GlcNAc-transferase 3
glucosaminyl (N-acetyl) transferase 3, mucin type pseudogene
NP_001159537.1
NP_001363928.1
XP_006517659.1
XP_006517660.1
XP_006517661.1
XP_006517663.1
XP_006517664.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166065.2 → NP_001159537.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

    See identical proteins and their annotated locations for NP_001159537.1

    Status: VALIDATED

    Source sequence(s)
    AC174082
    Consensus CDS
    CCDS49336.1
    UniProtKB/Swiss-Prot
    E9Q649
    Related
    ENSMUSP00000130496.2, ENSMUST00000171324.3
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

  2. NM_001376999.1 → NP_001363928.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC174082
    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    97060852..97087422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517597.3 → XP_006517660.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006517660.1

    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

  2. XM_006517598.3 → XP_006517661.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006517661.1

    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

  3. XM_006517596.5 → XP_006517659.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006517659.1

    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

  4. XM_006517600.2 → XP_006517663.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006517663.1

    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

  5. XM_006517601.4 → XP_006517664.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006517664.1

    UniProtKB/Swiss-Prot
    E9Q649
    Conserved Domains (1) summary
    cl27418
    Location:134 → 402
    Branch; Core-2/I-Branching enzyme

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019525.1: Suppressed sequence

    Description
    NG_019525.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q649.1 GenPept UniProtKB/Swiss-Prot:E9Q649

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