Pde8b phosphodiesterase 8B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde8bprovided by MGI
Official Full Name: phosphodiesterase 8Bprovided by MGI
Primary source: MGI:MGI:2443999
See related: Ensembl:ENSMUSG00000021684 AllianceGenome:MGI:2443999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230331L10Rik; C030047E14Rik
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including behavioral fear response; learning; and negative regulation of steroid hormone biosynthetic process. Is expressed in several structures, including alimentary system; central nervous system; hindlimb digit; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 17.9), cortex adult (RPKM 8.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 49.22 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (95160962..95386904, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (95024105..95250401, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of phosphodiesterase PDE8B reduces activation of primordial follicles in mouse ovaries.
Title: Inhibition of phosphodiesterase PDE8B reduces activation of primordial follicles in mouse ovaries.
Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.
Title: Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.
Pde8b knockout mice demonstrate improvement in select behaviors, motor-coordination, attenuation of age-induced motor coordination decline and increased anxiety levels.
Title: Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay.
findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low
Title: cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.
Phosphodiesterase 8B is a major regulator of pools of cyclic AMP that promote steroidogenesis.
Title: The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

D13Mit160 (e-PCR), detects polymorphism
- UniSTS:126981

BB359354 (e-PCR)
- UniSTS:208972

MHAa22e7.seq (e-PCR)
- UniSTS:125093

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Names: cell proliferation-inducing gene 22 protein

NP_001164140.1

EC 3.1.4.53

NP_001333711.1

EC 3.1.4.53

NP_001360932.1

EC 3.1.4.53

NP_001360933.1

EC 3.1.4.53

NP_001360934.1

EC 3.1.4.53

NP_001360935.1

EC 3.1.4.53

NP_001360936.1

EC 3.1.4.53

NP_001391617.1

EC 3.1.4.53

NP_001391618.1

EC 3.1.4.53

NP_001391619.1

EC 3.1.4.53

NP_001391620.1

EC 3.1.4.53

NP_001391621.1

EC 3.1.4.53

NP_001391622.1

EC 3.1.4.53

NP_001391623.1

EC 3.1.4.53

NP_001391624.1

EC 3.1.4.53

NP_001391625.1

EC 3.1.4.53

NP_758467.2

EC 3.1.4.53

XP_006517650.1

EC 3.1.4.53

XP_006517651.1

EC 3.1.4.53

XP_006517654.1

EC 3.1.4.53

XP_006517657.1

EC 3.1.4.53

XP_011242951.1

EC 3.1.4.53

XP_011242952.1

EC 3.1.4.53

XP_011242953.1

EC 3.1.4.53

XP_017170982.1

EC 3.1.4.53

XP_017170983.1

EC 3.1.4.53

XP_030103093.1

EC 3.1.4.53

XP_030103095.1

EC 3.1.4.53

XP_030103096.1

EC 3.1.4.53

XP_036013910.1

EC 3.1.4.53

XP_036013911.1

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170669.2 → NP_001164140.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

Consensus CDS

CCDS49331.1

UniProtKB/TrEMBL

E9PYP0, Q8BI47

Related

ENSMUSP00000124068.2, ENSMUST00000162292.8

Conserved Domains (3) summary

PHA02597
Location:158 → 311

30.2; hypothetical protein; Provisional

pfam00233
Location:517 → 764

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam08629
Location:1 → 47

PDE8; PDE8 phosphodiesterase
NM_001346782.2 → NP_001333711.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

Consensus CDS

CCDS84052.1

UniProtKB/TrEMBL

A6YR19, E9PX38

Related

ENSMUSP00000124704.2, ENSMUST00000162153.9
NM_001374003.1 → NP_001360932.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

UniProtKB/Swiss-Prot

E9Q4S1

Related

ENSMUSP00000128987.2, ENSMUST00000172104.8

Conserved Domains (4) summary

COG2202
Location:167 → 375

PAS; PAS domain [Signal transduction mechanisms]

pfam08629
Location:1 → 47

PDE8; PDE8 phosphodiesterase

pfam00233
Location:614 → 861

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:280 → 377

PAS_9; PAS domain
NM_001374004.1 → NP_001360933.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

UniProtKB/Swiss-Prot

E9Q4S1

Related

ENSMUSP00000070465.8, ENSMUST00000067082.14

Conserved Domains (4) summary

COG2202
Location:166 → 374

PAS; PAS domain [Signal transduction mechanisms]

pfam08629
Location:1 → 47

PDE8; PDE8 phosphodiesterase

pfam00233
Location:613 → 860

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:279 → 376

PAS_9; PAS domain
NM_001374005.1 → NP_001360934.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

UniProtKB/TrEMBL

Q8CFW8

Conserved Domains (2) summary

PHA02597
Location:54 → 207

30.2; hypothetical protein; Provisional

pfam00233
Location:413 → 660

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001374006.1 → NP_001360935.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

UniProtKB/TrEMBL

Q8CFW8

Conserved Domains (2) summary

PHA02597
Location:53 → 206

30.2; hypothetical protein; Provisional

pfam00233
Location:412 → 659

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001374007.1 → NP_001360936.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

UniProtKB/TrEMBL

A6YR19

Conserved Domains (3) summary

COG2202
Location:63 → 274

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:510 → 757

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:176 → 273

PAS_9; PAS domain
NM_001404688.1 → NP_001391617.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404689.1 → NP_001391618.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404690.1 → NP_001391619.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404691.1 → NP_001391620.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404692.1 → NP_001391621.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404693.1 → NP_001391622.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404694.1 → NP_001391623.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404695.1 → NP_001391624.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_001404696.1 → NP_001391625.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108
NM_172263.3 → NP_758467.2 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

Status: VALIDATED

Source sequence(s)

AC123034, AC134439, AC147108

Consensus CDS

CCDS49332.1

UniProtKB/TrEMBL

E9PXX4, Q8CFW8

Related

ENSMUSP00000124409.2, ENSMUST00000162412.8

Conserved Domains (4) summary

smart00091
Location:168 → 212

PAS; PAS domain

COG2202
Location:62 → 212

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:459 → 706

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:174 → 227

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

95160962..95386904 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247236.2 → XP_030103096.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

UniProtKB/TrEMBL

A6YR19

Conserved Domains (2) summary

pfam00233
Location:430 → 677

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:96 → 193

PAS_9; PAS domain
XM_030247233.2 → XP_030103093.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

UniProtKB/TrEMBL

A6YR19

Conserved Domains (3) summary

COG2202
Location:87 → 295

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:534 → 781

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:200 → 297

PAS_9; PAS domain
XM_036158017.1 → XP_036013910.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

UniProtKB/TrEMBL

A6YR19

Conserved Domains (1) summary

pfam00233
Location:383 → 630

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_011244649.4 → XP_011242951.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

See identical proteins and their annotated locations for XP_011242951.1

UniProtKB/TrEMBL

A6YR19

Conserved Domains (3) summary

COG2202
Location:43 → 254

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:490 → 737

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:156 → 253

PAS_9; PAS domain
XM_006517594.5 → XP_006517657.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

See identical proteins and their annotated locations for XP_006517657.1

UniProtKB/TrEMBL

A6YR19

Conserved Domains (3) summary

COG2202
Location:43 → 254

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:490 → 737

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:156 → 253

PAS_9; PAS domain
XM_030247235.2 → XP_030103095.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

UniProtKB/TrEMBL

A6YR19

Conserved Domains (2) summary

pfam00233
Location:430 → 677

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:96 → 193

PAS_9; PAS domain
XM_011244650.4 → XP_011242952.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

UniProtKB/TrEMBL

A6YR19

Conserved Domains (2) summary

pfam00233
Location:430 → 677

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:96 → 193

PAS_9; PAS domain
XM_006517591.5 → XP_006517654.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

UniProtKB/TrEMBL

A6YR19

Conserved Domains (3) summary

COG2202
Location:86 → 294

PAS; PAS domain [Signal transduction mechanisms]

pfam00233
Location:533 → 780

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:199 → 296

PAS_9; PAS domain
XM_036158018.1 → XP_036013911.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

UniProtKB/TrEMBL

A6YR19

Conserved Domains (2) summary

pfam00233
Location:376 → 623

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:42 → 139

PAS_9; PAS domain
XM_017315494.3 → XP_017170983.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X12

UniProtKB/TrEMBL

Q8CFW8

Conserved Domains (2) summary

pfam00233
Location:326 → 573

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:42 → 95

PAS_9; PAS domain
XM_011244651.4 → XP_011242953.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

UniProtKB/TrEMBL

A6YR19

Conserved Domains (2) summary

pfam00233
Location:376 → 623

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:42 → 139

PAS_9; PAS domain
XM_017315493.3 → XP_017170982.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

UniProtKB/TrEMBL

Q8CFW8

Conserved Domains (2) summary

PHA02597
Location:34 → 187

30.2; hypothetical protein; Provisional

pfam00233
Location:393 → 640

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006517588.5 → XP_006517651.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

UniProtKB/Swiss-Prot

E9Q4S1

Conserved Domains (2) summary

pfam08629
Location:1 → 47

PDE8; PDE8 phosphodiesterase

pfam00233
Location:566 → 813

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
XM_006517587.5 → XP_006517650.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

UniProtKB/Swiss-Prot

E9Q4S1

UniProtKB/TrEMBL

E9Q8J6

Related

ENSMUSP00000022192.6, ENSMUST00000022192.12

Conserved Domains (2) summary

pfam08629
Location:1 → 47

PDE8; PDE8 phosphodiesterase

pfam00233
Location:567 → 814

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase