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Ice1 interactor of little elongation complex ELL subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 218333, updated on 5-Mar-2024

Summary

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Official Symbol
Ice1provided by MGI
Official Full Name
interactor of little elongation complex ELL subunit 1provided by MGI
Primary source
MGI:MGI:2385865
See related
Ensembl:ENSMUSG00000034525 AllianceGenome:MGI:2385865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0947
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Predicted to be located in Cajal body; histone locus body; and transcriptionally active chromatin. Predicted to be part of transcription elongation factor complex. Orthologous to human ICE1 (interactor of little elongation complex ELL subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 34.3), whole brain E14.5 (RPKM 24.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C1; 13 35.97 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (70736808..70785958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (70588688..70637839, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36216 Neighboring gene STARR-seq mESC enhancer starr_34952 Neighboring gene STARR-seq mESC enhancer starr_34953 Neighboring gene RIKEN cDNA 1700100L14 gene Neighboring gene predicted gene, 36267 Neighboring gene STARR-seq mESC enhancer starr_34954 Neighboring gene STARR-seq mESC enhancer starr_34956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:70776299-70776482 Neighboring gene predicted gene, 40996 Neighboring gene RIKEN cDNA D030007L05 gene Neighboring gene predicted gene, 36377 Neighboring gene predicted gene, 36474 Neighboring gene predicted gene, 36426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Shen X, et al. Cell, 2009 Dec 24. PMID 20064376, Free PMC Article
  2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27742

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in histone locus body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
little elongation complex subunit 1
Names
interactor of little elongator complex ELL subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144837.3 → NP_659086.2  little elongation complex subunit 1

    See identical proteins and their annotated locations for NP_659086.2

    Status: VALIDATED

    Source sequence(s)
    AC113508
    Consensus CDS
    CCDS49309.1
    UniProtKB/Swiss-Prot
    E9Q286, Q6ZQ20
    Related
    ENSMUSP00000036482.6, ENSMUST00000043493.7
    Conserved Domains (2) summary
    pfam13870
    Location:53 → 185
    DUF4201; Domain of unknown function (DUF4201)
    cl09810
    Location:26 → 180
    DUF2031; Protein of unknown function (DUF2031)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    70736808..70785958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247229.2 → XP_030103089.1  little elongation complex subunit 1 isoform X1

    Conserved Domains (1) summary
    cl38910
    Location:1729 → 1754
    ATP-synt_F1_V1_A1_AB_FliI_C; ATP synthase, alpha/beta subunits of F1/V1/A1 complex, flagellum-specific ATPase FliI, C-terminal domain

RNA

  1. XR_382437.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q286.1 GenPept UniProtKB/Swiss-Prot:E9Q286

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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