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Spmap2 sperm microtubule associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 21830, updated on 21-Apr-2024

Summary

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Official Symbol
Spmap2provided by MGI
Official Full Name
sperm microtubule associated protein 2provided by MGI
Primary source
MGI:MGI:1338756
See related
Ensembl:ENSMUSG00000020317 AllianceGenome:MGI:1338756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Theg
Summary
Acts upstream of or within spermatogenesis. Predicted to be located in cytoplasm. Is expressed in large intestine; metanephros; ovary; submandibular gland; and testis. Orthologous to human THEG (theg spermatid protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 111.0) See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79412311..79422970, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79576477..79587136, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 2 Neighboring gene microRNA 6909 Neighboring gene MIER family member 2 Neighboring gene predicted gene, 51808 Neighboring gene C2 calcium-dependent domain containing 4C Neighboring gene SHC (Src homology 2 domain containing) transforming protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction. Nayernia K, et al. Biol Reprod, 1999 Jun. PMID 10330110
  2. Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. Mannan AU, et al. Biol Reprod, 2003 Sep. PMID 12748127
  3. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). Mannan A, et al. Cytogenet Cell Genet, 2000. PMID 11173852
  4. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. Yanaka N, et al. J Biol Chem, 2000 May 19. PMID 10747865
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of either the C-terminal or N-terminal regions of the Theg protein did not affect spermatogenesis or fertility in the mouse.
    Title: Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm microtubule associated protein 2
Names
testicular haploid expressed gene product
testicular haploid expressed gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428846.1 → NP_001415775.1  sperm microtubule associated protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132265

  2. NM_011583.4 → NP_035713.1  sperm microtubule associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132265
    Consensus CDS
    CCDS23977.1
    UniProtKB/Swiss-Prot
    Q6P8H9, Q9JMB1, Q9QZ27
    Related
    ENSMUSP00000020566.7, ENSMUST00000020566.7
    Conserved Domains (1) summary
    pfam14912
    Location:209 → 267
    THEG; Testicular haploid expressed repeat

  3. NM_199226.2 → NP_954696.1  sperm microtubule associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_954696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region, compared to isoform 1.
    Source sequence(s)
    AC132265
    Consensus CDS
    CCDS23978.1
    UniProtKB/Swiss-Prot
    Q9JMB1
    Related
    ENSMUSP00000076647.7, ENSMUST00000077433.13
    Conserved Domains (1) summary
    pfam14912
    Location:185 → 243
    THEG; Testicular haploid expressed repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79412311..79422970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513579.3 → XP_006513642.1  sperm microtubule associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam14912
    Location:212 → 267
    THEG; Testicular haploid expressed repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMB1.1 GenPept UniProtKB/Swiss-Prot:Q9JMB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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