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Thbs3 thrombospondin 3 [ Mus musculus (house mouse) ]

Gene ID: 21827, updated on 5-Mar-2024

Summary

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Official Symbol
Thbs3provided by MGI
Official Full Name
thrombospondin 3provided by MGI
Primary source
MGI:MGI:98739
See related
Ensembl:ENSMUSG00000028047 AllianceGenome:MGI:98739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSP3; Thbs-3
Summary
Predicted to enable heparin binding activity. Acts upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including brain; lung; musculoskeletal system; sensory organ; and urinary system. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 35.8), lung adult (RPKM 25.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.01 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89122470..89134148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89215180..89226841)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E11197 Neighboring gene STARR-seq mESC enhancer starr_08226 Neighboring gene predicted gene, 57704 Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene mucin 1, transmembrane

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling. Hankenson KD, et al. Curr Osteoporos Rep, 2010 Jun. PMID 20425613
  2. SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene. Collins M, et al. Nucleic Acids Res, 1996 Oct 1. PMID 8871542, Free PMC Article
  3. Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. Chen H, et al. FEBS Lett, 1996 May 27. PMID 8654563
  4. Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene. Bornstein P, et al. Genomics, 1993 Mar. PMID 8468055
  5. Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Hankenson KD, et al. Mol Cell Biol, 2005 Jul. PMID 15964815, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bone trabecula formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within growth plate cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within growth plate cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ossification involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thrombospondin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013691.3 → NP_038719.2  thrombospondin-3 precursor

    See identical proteins and their annotated locations for NP_038719.2

    Status: VALIDATED

    Source sequence(s)
    AC161600, BC053023, BP754474, CJ064850
    Consensus CDS
    CCDS17495.1
    UniProtKB/Swiss-Prot
    Q05895, Q6LCE0, Q7TN15
    UniProtKB/TrEMBL
    E9PWF0
    Related
    ENSMUSP00000029682.5, ENSMUST00000029682.11
    Conserved Domains (9) summary
    cd00054
    Location:316 → 352
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:528 → 550
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:551 → 586
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:457 → 491
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:552 → 586
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:741 → 938
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:378 → 407
    EGF_3; EGF domain
    cd16079
    Location:227 → 269
    TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
    cl22861
    Location:21 → 193
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RNA

  1. NR_149740.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132327, AC161600, BP754474
    Related
    ENSMUST00000126315.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89122470..89134148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501295.3 → XP_006501358.1  thrombospondin-3 isoform X1

    Conserved Domains (8) summary
    cd00054
    Location:111 → 147
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:323 → 345
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:346 → 381
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:252 → 286
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:346 → 381
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:536 → 733
    TSP_C; Thrombospondin C-terminal region
    pfam12947
    Location:173 → 202
    EGF_3; EGF domain
    NF000535
    Location:257 → 447
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05895.2 GenPept UniProtKB/Swiss-Prot:Q05895

Gene LinkOut

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