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Rnf144b ring finger protein 144B [ Mus musculus (house mouse) ]

Gene ID: 218215, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf144bprovided by MGI
Official Full Name
ring finger protein 144Bprovided by MGI
Primary source
MGI:MGI:2384986
See related
Ensembl:ENSMUSG00000038068 AllianceGenome:MGI:2384986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pir2; Ibrdc2; E130105P19Rik
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; negative regulation of apoptotic process; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in membrane and mitochondrion. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including bladder; cranium; hindbrain ventricular layer; jaw; and thoracic segment skeleton. Orthologous to human RNF144B (ring finger protein 144B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 19.3), testis adult (RPKM 8.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 24.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (47276196..47401470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (47122720..47247991)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1875 Neighboring gene lysine (K)-specific demethylase 1B Neighboring gene STARR-seq mESC enhancer starr_34433 Neighboring gene STARR-seq mESC enhancer starr_34434 Neighboring gene DEK proto-oncogene Neighboring gene RIKEN cDNA A930002C04 gene Neighboring gene predicted gene, 40935 Neighboring gene STARR-seq mESC enhancer starr_34435 Neighboring gene predicted gene, 40934 Neighboring gene predicted gene, 52039 Neighboring gene predicted gene, 53785 Neighboring gene STARR-seq mESC enhancer starr_34438 Neighboring gene STARR-seq mESC enhancer starr_34442 Neighboring gene predicted gene, 57608 Neighboring gene predicted gene, 35733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Sayan BS, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615966, Free PMC Article
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
    Title: Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
  2. PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2]
    Title: Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC32473

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF144B
Names
IBR domain containing 2
IBR domain-containing protein 2
NP_001164114.1
NP_666154.3
XP_036013887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170643.1 → NP_001164114.1  E3 ubiquitin-protein ligase RNF144B

    See identical proteins and their annotated locations for NP_001164114.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131085, AK040939, BB661852
    Consensus CDS
    CCDS26491.1
    UniProtKB/Swiss-Prot
    Q8BG97, Q8BKD6, Q8R195
    Related
    ENSMUSP00000105738.3, ENSMUST00000110111.4
    Conserved Domains (2) summary
    smart00647
    Location:101 → 166
    IBR; In Between Ring fingers
    pfam01485
    Location:183 → 223
    IBR; IBR domain, a half RING-finger domain

  2. NM_146042.4 → NP_666154.3  E3 ubiquitin-protein ligase RNF144B

    See identical proteins and their annotated locations for NP_666154.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131085, AK040939, AK053529
    Consensus CDS
    CCDS26491.1
    UniProtKB/Swiss-Prot
    Q8BG97, Q8BKD6, Q8R195
    Related
    ENSMUSP00000071017.5, ENSMUST00000068891.12
    Conserved Domains (2) summary
    smart00647
    Location:101 → 166
    IBR; In Between Ring fingers
    pfam01485
    Location:183 → 223
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    47276196..47401470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157994.1 → XP_036013887.1  E3 ubiquitin-protein ligase RNF144B isoform X1

    Conserved Domains (3) summary
    smart00647
    Location:66 → 131
    IBR; In Between Ring fingers
    pfam01485
    Location:148 → 188
    IBR; IBR domain, a half RING-finger domain
    cl17238
    Location:28 → 55
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKD6.2 GenPept UniProtKB/Swiss-Prot:Q8BKD6

Gene LinkOut

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