Tgif1 TGFB-induced factor homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgif1provided by MGI
Official Full Name: TGFB-induced factor homeobox 1provided by MGI
Primary source: MGI:MGI:1194497
See related: Ensembl:ENSMUSG00000047407 AllianceGenome:MGI:1194497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tgif
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including negative regulation of retinoic acid receptor signaling pathway; nodal signaling pathway; and positive regulation of fibroblast proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo ectoderm; and genitourinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 15.8), bladder adult (RPKM 9.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 41.87 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (71151200..71160527, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (70844205..70853532, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TG-Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia.
Title: Loss of TG-Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia.
Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment.
Title: Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment.
our results suggest that proper control of TGF-beta/Smads/CRMP2 signaling pathways is critical for the precise execution of neuronal morphogenesis, whose impairment eventually results in neurodevelopmental disorders
Title: Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression.
Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers.
Title: TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
Tgif1 is a novel regulator of bone remodeling and an essential component of the PTH anabolic action.
Title: TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
Zic2-binding to the cis-regulatory element near the Tgif1 promoter may be involved in the mechanism underlying forebrain development and incidences of holoprosencephaly.
Title: Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.
Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.complex cross-regulatory network of HOXA1 and TALE proteins. This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins
Title: HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets.
Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2
Title: Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
Tgif2 participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors.
Title: Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tgif1 (e-PCR), detects polymorphism
- UniSTS:469809

AI462167 (e-PCR)
- UniSTS:181059

AA959811 (e-PCR)
- UniSTS:160689

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nodal signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein TGIF1

Names: 5'-TG-3'-interacting factor 1; TALE family homeobox; TG interacting factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164074.1 → NP_001157546.1 homeobox protein TGIF1 isoform c

See identical proteins and their annotated locations for NP_001157546.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.

Source sequence(s)

AC079441, AK160193, BY096128

Consensus CDS

CCDS50174.1

UniProtKB/TrEMBL

D3Z0Q5, Q3TVD4

Related

ENSMUSP00000113192.2, ENSMUST00000118283.8

Conserved Domains (1) summary

pfam05920
Location:33 → 72

Homeobox_KN; Homeobox KN domain
NM_001164075.1 → NP_001157547.1 homeobox protein TGIF1 isoform a

See identical proteins and their annotated locations for NP_001157547.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC079441, CT009715

Consensus CDS

CCDS50175.1

UniProtKB/TrEMBL

G3UWC5

Related

ENSMUSP00000130930.3, ENSMUST00000166395.9

Conserved Domains (1) summary

pfam05920
Location:86 → 125

Homeobox_KN; Homeobox KN domain
NM_001164076.1 → NP_001157548.1 homeobox protein TGIF1 isoform c

See identical proteins and their annotated locations for NP_001157548.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.

Source sequence(s)

AC079441

Consensus CDS

CCDS50174.1

UniProtKB/TrEMBL

D3Z0Q5, Q3TVD4

Related

ENSMUSP00000127139.2, ENSMUST00000172229.8

Conserved Domains (1) summary

pfam05920
Location:33 → 72

Homeobox_KN; Homeobox KN domain
NM_001164077.1 → NP_001157549.1 homeobox protein TGIF1 isoform c

See identical proteins and their annotated locations for NP_001157549.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.

Source sequence(s)

AC079441

Consensus CDS

CCDS50174.1

UniProtKB/TrEMBL

D3Z0Q5, Q3TVD4

Conserved Domains (1) summary

pfam05920
Location:33 → 72

Homeobox_KN; Homeobox KN domain
NM_001424959.1 → NP_001411888.1 homeobox protein TGIF1 isoform d

Status: VALIDATED

Source sequence(s)

AC079441
NM_001424962.1 → NP_001411891.1 homeobox protein TGIF1 isoform c

Status: VALIDATED

Source sequence(s)

AC079441

UniProtKB/TrEMBL

Q3TVD4
NM_009372.3 → NP_033398.2 homeobox protein TGIF1 isoform b

See identical proteins and their annotated locations for NP_033398.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct start codon, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a.

Source sequence(s)

AC079441, AK008909, AK160193, CD563532

Consensus CDS

CCDS37683.1

UniProtKB/Swiss-Prot

P70284, Q921F9, Q99JS3

UniProtKB/TrEMBL

D3Z0Q5

Related

ENSMUSP00000060512.9, ENSMUST00000059775.15

Conserved Domains (1) summary

pfam05920
Location:53 → 92

Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

71151200..71160527 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160474.1 → XP_036016367.1 homeobox protein TGIF1 isoform X2

UniProtKB/TrEMBL

D3Z0Q5

Conserved Domains (1) summary

pfam05920
Location:52 → 91

Homeobox_KN; Homeobox KN domain