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Mboat1 membrane bound O-acyltransferase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 218121, updated on 11-Apr-2024

Summary

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Official Symbol
Mboat1provided by MGI
Official Full Name
membrane bound O-acyltransferase domain containing 1provided by MGI
Primary source
MGI:MGI:2387184
See related
Ensembl:ENSMUSG00000038732 AllianceGenome:MGI:2387184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPEAT; LPSAT; Oact1; LPEAT1; Moact1; LPLAT 1; 9130215M02Rik
Summary
Enables 1-acylglycerophosphoethanolamine O-acyltransferase activity. Involved in phosphatidylethanolamine acyl-chain remodeling; phospholipid biosynthetic process; and regulation of neuron projection development. Located in endoplasmic reticulum membrane. Is expressed in several structures, including gut; integumental system; nervous system; respiratory system; and urinary system. Orthologous to human MBOAT1 (membrane bound O-acyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 26.9), stomach adult (RPKM 19.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.2; 13 13.14 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30320499..30430677)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30136451..30246694)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E9871 Neighboring gene STARR-positive B cell enhancer ABC_E211 Neighboring gene STARR-seq mESC enhancer starr_34059 Neighboring gene STARR-seq mESC enhancer starr_34060 Neighboring gene predicted gene, 40860 Neighboring gene STARR-seq mESC enhancer starr_34062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30176986-30177169 Neighboring gene STARR-seq mESC enhancer starr_34063 Neighboring gene predicted gene, 23206 Neighboring gene predicted gene, 40869 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_34065 Neighboring gene predicted gene, 40863 Neighboring gene predicted gene, 53782 Neighboring gene STARR-seq mESC enhancer starr_34066 Neighboring gene angiotensin II receptor, type 1a Neighboring gene STARR-seq mESC enhancer starr_34067 Neighboring gene STARR-seq mESC enhancer starr_34068 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. Tabe S, et al. FASEB J, 2016 Jul. PMID 27048541
  2. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Hishikawa D, et al. Proc Natl Acad Sci U S A, 2008 Feb 26. PMID 18287005, Free PMC Article
  3. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. Tamaki H, et al. J Biol Chem, 2007 Nov 23. PMID 17890783
  4. Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Wedel M, et al. Nucleic Acids Res, 2020 May 21. PMID 32266943, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-acylglycerophosphoserine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysophospholipid acyltransferase 1
Names
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoethanolamine O-acyltransferase
1-acylglycerophosphoethanolamine O-acyltransferase MBOAT1
1-acylglycerophosphoserine O-acyltransferase
1-acylglycerophosphoserine O-acyltransferase MBOAT1
LPE acyltransferase 1
O-acyltransferase (membrane bound) domain containing 1
O-acyltransferase domain-containing protein 1
lyso-PE acyltransferase
lyso-PS acyltransferase
lysophosphatidylethanolamine acyltransferase
lysophosphatidylethanolamine acyltransferase 1
lysophosphatidylserine acyltransferase
membrane bound O-acyl transferase family, member 1
membrane-bound O-acyltransferase domain-containing protein 1
NP_001405885.1
NP_001405886.1
NP_001405887.1
NP_001405888.1
NP_705774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418956.1 → NP_001405885.1  lysophospholipid acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749

  2. NM_001418957.1 → NP_001405886.1  lysophospholipid acyltransferase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749

  3. NM_001418958.1 → NP_001405887.1  lysophospholipid acyltransferase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749

  4. NM_001418959.1 → NP_001405888.1  lysophospholipid acyltransferase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749

  5. NM_153546.5 → NP_705774.1  lysophospholipid acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_705774.1

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749
    Consensus CDS
    CCDS26414.1
    UniProtKB/Swiss-Prot
    A9EDS0, Q8BH98, Q8R3T2
    Related
    ENSMUSP00000045441.9, ENSMUST00000047311.16
    Conserved Domains (1) summary
    cl00738
    Location:21 → 458
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_184863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL450321, AL645749

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30320499..30430677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH98.1 GenPept UniProtKB/Swiss-Prot:Q8BH98

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