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Tsc22d1 TSC22 domain family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 21807, updated on 21-Apr-2024

Summary

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Official Symbol
Tsc22d1provided by MGI
Official Full Name
TSC22 domain family, member 1provided by MGI
Primary source
MGI:MGI:109127
See related
Ensembl:ENSMUSG00000022010 AllianceGenome:MGI:109127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsc; Egr5; Tsc22; TSC-22; Gm19597; Tgfb1i4
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of apoptotic process; positive regulation of apoptotic process; and positive regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 53.8), CNS E14 (RPKM 43.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 40.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76652401..76745205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76414961..76507765)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900040C04 gene Neighboring gene VISTA enhancer mm1502 Neighboring gene STARR-seq mESC enhancer starr_37174 Neighboring gene predicted gene, 41215 Neighboring gene STARR-seq mESC enhancer starr_37176 Neighboring gene STARR-seq mESC enhancer starr_37178 Neighboring gene STARR-seq mESC enhancer starr_37179 Neighboring gene STARR-positive B cell enhancer ABC_E2428 Neighboring gene STARR-seq mESC enhancer starr_37180 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene STARR-seq mESC enhancer starr_37182 Neighboring gene predicted gene, 36845 Neighboring gene stress-associated endoplasmic reticulum protein family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of TSC-22 (transforming growth factor- β-stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice. Uchida D, et al. Oncotarget, 2016 Mar 22. PMID 26872059, Free PMC Article
  2. TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Yu J, et al. Blood, 2009 May 28. PMID 19329776, Free PMC Article
  3. Profile of transforming growth factor-beta responses during the murine hair cycle. Soma T, et al. J Invest Dermatol, 2003 Nov. PMID 14708594
  4. Neurovascular Development in Pten and Tsc2 Mouse Mutants. Dusing M, et al. eNeuro, 2023 Feb. PMID 36759189, Free PMC Article
  5. TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes. Pépin A, et al. J Cell Biochem, 2016 Aug. PMID 26752201

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurovascular Development in Pten and Tsc2 Mouse Mutants.
    Title: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
  2. High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma.
    Title: Overexpression of TSC-22 (transforming growth factor- β-stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice.
  3. These results suggested that TSC-22 could counteract the protective effect of GILZ on IL-2-deprivation-induced apoptosis.
    Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.
  4. Fat4 and Tsc22d1 are likely candidate genes to influence formation of spontaneous pulmonary adenoma in aging male and female mice, respectively.
    Title: Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.
  5. post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-beta-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy
    Title: Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.
  6. novel opposing functions of the two mammalian TSC-22D1 isoforms in cell survival and proliferation, and establish the TSC-22D1 isoform 2 as a potential regulator of cell death during mammary gland involution
    Title: TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.
  7. TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.
    Title: TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia.
  8. Analysis of the regulation of Tgf beta1i4 by Foxc1 in mesenchymal cells isolated from the periocular region revealed that Foxc1 negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1.
    Title: Identification of Tgf beta1i4 as a downstream target of Foxc1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TSC22 domain family protein 1
Names
Tgfb-stimulated clone 22 homolog
Tsc22-related inducible leucine zipper 1b
regulatory protein Tsc22
transforming growth factor beta 1 induced transcript 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177751.2 → NP_001171222.1  TSC22 domain family protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC142266, AI841546, AK147039, BY720238
    Consensus CDS
    CCDS49545.1
    UniProtKB/TrEMBL
    D3YW86
    Related
    ENSMUSP00000099140.3, ENSMUST00000101618.9
    Conserved Domains (1) summary
    pfam01166
    Location:22 → 68
    TSC22; TSC-22/dip/bun family

  2. NM_001310646.1 → NP_001297575.1  TSC22 domain family protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001297575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate splice structure in its 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC134842, AI841546, AW546174, CX220910
    Consensus CDS
    CCDS79344.1
    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    UniProtKB/TrEMBL
    D3Z0V7
    Related
    ENSMUSP00000106513.2, ENSMUST00000110888.8
    Conserved Domains (2) summary
    PHA03247
    Location:486 → 796
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:910 → 956
    TSC22; TSC-22/dip/bun family

  3. NM_001310647.1 → NP_001297576.1  TSC22 domain family protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001297576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks the 5' and central coding regions, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (5) is significantly shorter than isoform 1.
    Source sequence(s)
    AI841546, AW546174, CX220910
    Consensus CDS
    CCDS79345.1
    UniProtKB/TrEMBL
    H3BLI9
    Related
    ENSMUSP00000135296.2, ENSMUST00000177207.2
    Conserved Domains (1) summary
    cl40461
    Location:1 → 74
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  4. NM_009366.4 → NP_033392.1  TSC22 domain family protein 1 isoform 2

    See identical proteins and their annotated locations for NP_033392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI841546, AK147039
    Consensus CDS
    CCDS27286.1
    UniProtKB/TrEMBL
    Q3UXU0
    Related
    ENSMUSP00000022587.10, ENSMUST00000022587.10
    Conserved Domains (1) summary
    cd21938
    Location:53 → 131
    ZIP_TSC22D1; leucine zipper domain found in TSC22 domain family protein 1

  5. NM_207652.3 → NP_997535.2  TSC22 domain family protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI841546, AK147039, BC058660
    Consensus CDS
    CCDS27285.2
    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    UniProtKB/TrEMBL
    E9QLZ1
    Related
    ENSMUSP00000044517.9, ENSMUST00000048371.15
    Conserved Domains (2) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:992 → 1038
    TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    76652401..76745205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315943.2 → XP_017171432.1  TSC22 domain family protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    UniProtKB/TrEMBL
    E9QLZ1
    Conserved Domains (2) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:992 → 1038
    TSC22; TSC-22/dip/bun family

  2. XM_017315942.2 → XP_017171431.1  TSC22 domain family protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    UniProtKB/TrEMBL
    E9QLZ1
    Conserved Domains (2) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:992 → 1038
    TSC22; TSC-22/dip/bun family

  3. XM_006518803.4 → XP_006518866.1  TSC22 domain family protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006518866.1

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    UniProtKB/TrEMBL
    D3Z0V7
    Conserved Domains (2) summary
    PHA03247
    Location:486 → 796
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:910 → 956
    TSC22; TSC-22/dip/bun family

  4. XM_017315945.2 → XP_017171434.1  TSC22 domain family protein 1 isoform X5

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    Conserved Domains (1) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional

  5. XM_006518799.3 → XP_006518862.1  TSC22 domain family protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    Conserved Domains (1) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional

  6. XM_006518801.3 → XP_006518864.1  TSC22 domain family protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    Conserved Domains (1) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional

  7. XM_006518800.3 → XP_006518863.1  TSC22 domain family protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    Conserved Domains (1) summary
    PHA03247
    Location:568 → 878
    PHA03247; large tegument protein UL36; Provisional

  8. XM_036158535.1 → XP_036014428.1  TSC22 domain family protein 1 isoform X7

    UniProtKB/Swiss-Prot
    P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
    Conserved Domains (1) summary
    PHA03247
    Location:486 → 796
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_004938376.1 RNA Sequence

  2. XR_003950835.1 RNA Sequence

  3. XR_001781104.2 RNA Sequence

  4. XR_001781105.2 RNA Sequence

  5. XR_383154.3 RNA Sequence

  6. XR_003950836.1 RNA Sequence

  7. XR_004938375.1 RNA Sequence

  8. XR_383156.3 RNA Sequence

  9. XR_003950837.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62500.2 GenPept UniProtKB/Swiss-Prot:P62500

Gene LinkOut

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