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Tmem196 transmembrane protein 196 [ Mus musculus (house mouse) ]

Gene ID: 217951, updated on 13-Apr-2024

Summary

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Official Symbol
Tmem196provided by MGI
Official Full Name
transmembrane protein 196provided by MGI
Primary source
MGI:MGI:2685374
See related
Ensembl:ENSMUSG00000048004 AllianceGenome:MGI:2685374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm528
Summary
Is expressed in brain. Orthologous to human TMEM196 (transmembrane protein 196). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.8), cortex adult (RPKM 2.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F2; 12 63.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119909422..119984981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119946127..120021242)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene NOP2 nucleolar protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_33458 Neighboring gene STARR-seq mESC enhancer starr_33459 Neighboring gene STARR-seq mESC enhancer starr_33460 Neighboring gene STARR-seq mESC enhancer starr_33461 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33462 Neighboring gene STARR-seq mESC enhancer starr_33463

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway. Chen J, et al. J Cancer Res Clin Oncol, 2023 Feb. PMID 36355209
  2. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM196 inhibits lung cancer metastasis by regulating the Wnt/beta-catenin signaling pathway.
    Title: TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 196

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160385.3 → NP_001153857.1  transmembrane protein 196 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC164110, AC225445
    Consensus CDS
    CCDS49200.1
    UniProtKB/Swiss-Prot
    D3YWQ9
    Related
    ENSMUSP00000054994.8, ENSMUST00000058644.15

  2. NM_001294146.2 → NP_001281075.1  transmembrane protein 196 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC164110, AC225445
    Consensus CDS
    CCDS79159.1
    UniProtKB/TrEMBL
    V9GX04
    Related
    ENSMUSP00000138921.2, ENSMUST00000183694.8

  3. NM_001294154.2 → NP_001281083.1  transmembrane protein 196 isoform 3

    See identical proteins and their annotated locations for NP_001281083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate exon, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC164110, AC225445
    UniProtKB/TrEMBL
    V9GX16
    Related
    ENSMUSP00000138937.2, ENSMUST00000184820.8

  4. NM_001379146.1 → NP_001366075.1  transmembrane protein 196 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC164110, AC225445
    UniProtKB/TrEMBL
    V9GX78
    Related
    ENSMUSP00000139022.2, ENSMUST00000184069.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    119909422..119984981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157376.1 → XP_036013269.1  transmembrane protein 196 isoform X1

    UniProtKB/TrEMBL
    V9GX16
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YWQ9.2 GenPept UniProtKB/Swiss-Prot:D3YWQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous