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Cdca7l cell division cycle associated 7 like [ Mus musculus (house mouse) ]

Gene ID: 217946, updated on 5-Mar-2024

Summary

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Official Symbol
Cdca7lprovided by MGI
Official Full Name
cell division cycle associated 7 likeprovided by MGI
Primary source
MGI:MGI:2384982
See related
Ensembl:ENSMUSG00000021175 AllianceGenome:MGI:2384982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JPO2
Summary
Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human CDCA7L (cell division cycle associated 7 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.1), liver E14 (RPKM 4.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F2; 12 63.2 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117807209..117842441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117843475..117878712)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119003289-119003590 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:119058566-119058867 Neighboring gene STARR-seq mESC enhancer starr_33427 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene dynein, axonemal, heavy chain 11 Neighboring gene STARR-seq mESC enhancer starr_33429 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119539914-119540215 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119540362-119540663 Neighboring gene trans-acting transcription factor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119611733-119611916 Neighboring gene STARR-seq mESC enhancer starr_33430 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119615690-119615886 Neighboring gene predicted gene, 25577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription. Xiao M, et al. Exp Clin Endocrinol Diabetes, 2023 Mar. PMID 36893788
  2. Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12. Amlin-Van Schaick JC, et al. Neuro Oncol, 2012 Feb. PMID 22234937, Free PMC Article
  3. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Ou XM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16829576, Free PMC Article
  4. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Huang A, et al. Cancer Res, 2005 Jul 1. PMID 15994933
  5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
    Title: E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
  2. Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc.
    Title: Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11998

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle-associated 7-like protein
Names
transcription factor RAM2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412933.1 → NP_001399862.1  cell division cycle-associated 7-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139993

  2. NM_001412934.1 → NP_001399863.1  cell division cycle-associated 7-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139993

  3. NM_001412935.1 → NP_001399864.1  cell division cycle-associated 7-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139993

  4. NM_146040.2 → NP_666152.1  cell division cycle-associated 7-like protein isoform 3

    See identical proteins and their annotated locations for NP_666152.1

    Status: VALIDATED

    Source sequence(s)
    AC139993, AK149673
    Consensus CDS
    CCDS49197.1
    UniProtKB/Swiss-Prot
    Q922M5
    Related
    ENSMUSP00000021592.10, ENSMUST00000021592.16
    Conserved Domains (1) summary
    pfam10497
    Location:333 → 431
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RNA

  1. NR_182072.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139993

  2. NR_182073.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC139993

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    117807209..117842441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244100.4 → XP_011242402.3  cell division cycle-associated 7-like protein isoform X4

    Conserved Domains (1) summary
    pfam10497
    Location:363 → 416
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922M5.1 GenPept UniProtKB/Swiss-Prot:Q922M5

Gene LinkOut

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