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Dync2i1 dynein 2 intermediate chain 1 [ Mus musculus (house mouse) ]

Gene ID: 217935, updated on 5-Mar-2024

Summary

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Official Symbol
Dync2i1provided by MGI
Official Full Name
dynein 2 intermediate chain 1provided by MGI
Primary source
MGI:MGI:2445085
See related
Ensembl:ENSMUSG00000042050 AllianceGenome:MGI:2445085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr60; Dync2l1; D430033N04Rik
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to act upstream of or within cell projection organization. Located in cilium. Is expressed in mandible; maxilla; olfactory epithelium; and orbito-sphenoid. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 6.3), frontal lobe adult (RPKM 3.7) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Dync2i1 in Genome Data Viewer
Location:
12 F2; 12 62.65 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116169881..116226665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116206261..116263046, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33401 Neighboring gene predicted gene, 23732 Neighboring gene STARR-positive B cell enhancer ABC_E10777 Neighboring gene predicted gene, 46330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:117519461-117519695 Neighboring gene extended synaptotagmin-like protein 2 Neighboring gene RIKEN cDNA 2310058N22 gene Neighboring gene RIKEN cDNA D430020J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4047

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development. Li C, et al. Cell Death Dis, 2021 Jan 12. PMID 33436552, Free PMC Article
  2. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
  3. Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Yan L, et al. Front Cell Dev Biol, 2023. PMID 37228654, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC29335

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light chain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary retrograde transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with ciliary base ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with interphase microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 2 intermediate chain 1
Names
WD repeat domain 60
WD repeat-containing protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146039.3 → NP_666151.3  cytoplasmic dynein 2 intermediate chain 1

    See identical proteins and their annotated locations for NP_666151.3

    Status: VALIDATED

    Source sequence(s)
    AK052482, AK144444, CJ150229
    Consensus CDS
    CCDS36575.1
    UniProtKB/Swiss-Prot
    Q3UNM4, Q8C761
    Related
    ENSMUSP00000047334.7, ENSMUST00000039349.8
    Conserved Domains (4) summary
    COG2319
    Location:570 → 966
    WD40; WD40 repeat [General function prediction only]
    pfam12871
    Location:52 → 133
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    sd00039
    Location:808 → 844
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:639 → 927
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116169881..116226665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515780.5 → XP_006515843.1  cytoplasmic dynein 2 intermediate chain 1 isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:48 → 396
    PTZ00121; MAEBL; Provisional
    COG2319
    Location:604 → 1000
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:842 → 878
    7WD40; WD40 repeat [structural motif]

  2. XM_036157371.1 → XP_036013264.1  cytoplasmic dynein 2 intermediate chain 1 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:430 → 826
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:668 → 704
    7WD40; WD40 repeat [structural motif]
    cl27104
    Location:69 → 233
    Mak16; Mak16 protein C-terminal region

  3. XM_011244097.4 → XP_011242399.1  cytoplasmic dynein 2 intermediate chain 1 isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:145 → 541
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:383 → 419
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_381520.5 RNA Sequence

  2. XR_004937492.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C761.1 GenPept UniProtKB/Swiss-Prot:Q8C761

Gene LinkOut

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