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Cdc42bpb CDC42 binding protein kinase beta [ Mus musculus (house mouse) ]

Gene ID: 217866, updated on 11-Apr-2024

Summary

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Official Symbol
Cdc42bpbprovided by MGI
Official Full Name
CDC42 binding protein kinase betaprovided by MGI
Primary source
MGI:MGI:2136459
See related
Ensembl:ENSMUSG00000021279 AllianceGenome:MGI:2136459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRCKb
Summary
Predicted to enable protein serine/threonine kinase activity and small GTPase binding activity. Predicted to be involved in actomyosin structure organization; cell migration; and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cell junction; cell projection; and plasma membrane. Predicted to be active in actomyosin and cytoplasm. Orthologous to human CDC42BPB (CDC42 binding protein kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 48.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc42bpb in Genome Data Viewer
Location:
12 F1; 12 60.94 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111259406..111347985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111292972..111379313, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930595D18 gene Neighboring gene TNF receptor-associated factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112477093-112477276 Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene predicted gene, 51960 Neighboring gene amnionless Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MRCKβ links Dasm1 to actin rearrangements to promote dendrite development. Wang XX, et al. J Biol Chem, 2021 Jan-Jun. PMID 33933448, Free PMC Article
  2. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. Kalantry S, et al. Nat Genet, 2001 Apr. PMID 11279523
  3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  4. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
  5. An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Witherden AS, et al. Gene, 2002 Jan 23. PMID 11867214

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development.
    Title: MRCKβ links Dasm1 to actin rearrangements to promote dendrite development.
  2. First identified and named MRCKb based on sequence similarity to MRCKa (CDC42bpa) and orthology to human MRCKb/CDC42bpb
    Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK beta
Names
DMPK-like beta
MRCK beta
myotonic dystrophy kinase related CDC42 binding kinase beta
myotonic dystrophy protein kinase like beta
NP_898837.2
XP_006515826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183016.2 → NP_898837.2  serine/threonine-protein kinase MRCK beta

    See identical proteins and their annotated locations for NP_898837.2

    Status: VALIDATED

    Source sequence(s)
    AC127580
    Consensus CDS
    CCDS26176.1
    UniProtKB/Swiss-Prot
    E9QK15, Q69ZR5, Q7TT50, Q80W33
    UniProtKB/TrEMBL
    B2RQQ7
    Related
    ENSMUSP00000042565.4, ENSMUST00000041965.5
    Conserved Domains (8) summary
    pfam08826
    Location:878 → 939
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:76 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:1027 → 1076
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1086 → 1220
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05624
    Location:3 → 411
    STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
    pfam00780
    Location:1246 → 1512
    CNH; CNH domain
    pfam13868
    Location:426 → 786
    TPH; Trichohyalin-plectin-homology domain
    pfam15796
    Location:528 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111259406..111347985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515763.4 → XP_006515826.1  serine/threonine-protein kinase MRCK beta isoform X1

    UniProtKB/TrEMBL
    B2RQQ7
    Conserved Domains (6) summary
    COG0419
    Location:429 → 933
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:1044 → 1093
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:1103 → 1237
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05624
    Location:3 → 411
    STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
    pfam00780
    Location:1263 → 1529
    CNH; CNH domain
    pfam15796
    Location:527 → 606
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RNA

  1. XR_004937489.1 RNA Sequence

  2. XR_001780447.3 RNA Sequence

  3. XR_004937490.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT50.2 GenPept UniProtKB/Swiss-Prot:Q7TT50

Gene LinkOut

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