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Ahsa1 AHA1, activator of heat shock protein ATPase 1 [ Mus musculus (house mouse) ]

Gene ID: 217737, updated on 5-Mar-2024

Summary

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Official Symbol
Ahsa1provided by MGI
Official Full Name
AHA1, activator of heat shock protein ATPase 1provided by MGI
Primary source
MGI:MGI:2387603
See related
Ensembl:ENSMUSG00000021037 AllianceGenome:MGI:2387603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38
Summary
Enables Hsp90 protein binding activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 69.2), CNS E11.5 (RPKM 67.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ahsa1 in Genome Data Viewer
Location:
12 D2; 12 41.47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87313189..87320772)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87266415..87273998)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E9041 Neighboring gene sterile alpha motif domain containing 15 Neighboring gene NADP+ dependent oxidoreductase domain containing 1 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene predicted gene, 53736 Neighboring gene STARR-seq mESC enhancer starr_32874 Neighboring gene isthmin 2 Neighboring gene predicted gene, 51956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of the cochaperone AHA1 regulates heat-shock protein 90 and endothelial NO synthase activation by vascular endothelial growth factor. Desjardins F, et al. Arterioscler Thromb Vasc Biol, 2012 Oct. PMID 22859491
  2. Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Xu W, et al. Mol Cell, 2012 Aug 10. PMID 22727666, Free PMC Article
  3. An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine. Echeverría PC, et al. PLoS One, 2011. PMID 22022502, Free PMC Article
  4. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. Woodford MR, et al. EMBO J, 2017 Dec 15. PMID 29127155, Free PMC Article
  5. Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Piazzi M, et al. Mol Cell Proteomics, 2013 Aug. PMID 23665500, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36589, MGC36618

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 1
Names
AHA1, activator of heat shock 90kDa protein ATPase homolog 1
AHA1, activator of heat shock protein ATPase homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422806.1 → NP_001409735.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151967

  2. NM_146036.2 → NP_666148.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_666148.1

    Status: VALIDATED

    Source sequence(s)
    AC151967
    Consensus CDS
    CCDS26075.1
    UniProtKB/Swiss-Prot
    Q8BK64, Q8R3E6
    UniProtKB/TrEMBL
    Q3TL79
    Related
    ENSMUSP00000021425.7, ENSMUST00000021425.8
    Conserved Domains (2) summary
    cd08892
    Location:208 → 333
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29 → 158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87313189..87320772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BK64.2 GenPept UniProtKB/Swiss-Prot:Q8BK64

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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