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Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9 [ Mus musculus (house mouse) ]

Gene ID: 217718, updated on 21-Apr-2024

Summary

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Official Symbol
Nek9provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 9provided by MGI
Primary source
MGI:MGI:2387995
See related
Ensembl:ENSMUSG00000034290 AllianceGenome:MGI:2387995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130021H08Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within cell division and phosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 19.2), heart adult (RPKM 16.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D2; 12 39.63 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85346288..85386136, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85299514..85339362, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mutL homolog 3 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32767 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86621244-86621431 Neighboring gene zinc finger, C2HC-type containing 1C Neighboring gene STARR-positive B cell enhancer ABC_E7161 Neighboring gene acylphosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_32769 Neighboring gene STARR-seq mESC enhancer starr_32770 Neighboring gene STARR-seq mESC enhancer starr_32772 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene STARR-seq mESC enhancer starr_32773 Neighboring gene STARR-positive B cell enhancer ABC_E7162 Neighboring gene predicted gene, 51954

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response. Smith SC, et al. Nucleic Acids Res, 2014 Oct. PMID 25217585, Free PMC Article
  2. Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis. Yang SW, et al. Cell Cycle, 2012 Dec 1. PMID 23159858, Free PMC Article
  3. Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase. Pelka P, et al. J Cell Physiol, 2007 Jul. PMID 17443675
  4. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Yamamoto Y, et al. Nat Commun, 2021 Jun 2. PMID 34078910, Free PMC Article
  5. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction.
    Title: Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction.
  2. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
    Title: NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
  3. NEK9 is a critical component of the replication stress response that promotes CHK1 activity, maintaining genome integrity following challenges to DNA replication.
    Title: A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.
  4. Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores.
    Title: Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek9
Names
nercc1 kinase
never in mitosis A-related kinase 9
nimA-related protein kinase 9
NP_660120.2
XP_006515771.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145138.2 → NP_660120.2  serine/threonine-protein kinase Nek9

    See identical proteins and their annotated locations for NP_660120.2

    Status: VALIDATED

    Source sequence(s)
    AK173323, BQ964444, BY343854, CD775651
    Consensus CDS
    CCDS26057.1
    UniProtKB/Swiss-Prot
    Q148U2, Q8K1R7, Q8R3P1
    UniProtKB/TrEMBL
    Q69Z43
    Related
    ENSMUSP00000049056.8, ENSMUST00000040992.8
    Conserved Domains (3) summary
    smart00220
    Location:52 → 296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08221
    Location:51 → 296
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
    pfam00415
    Location:500 → 547
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85346288..85386136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515708.5 → XP_006515771.1  serine/threonine-protein kinase Nek9 isoform X1

    Conserved Domains (4) summary
    COG5184
    Location:136 → 479
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl30263
    Location:692 → 746
    PRK14127; cell division regulator GpsB
    pfam00415
    Location:459 → 514
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl21453
    Location:2 → 87
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1R7.2 GenPept UniProtKB/Swiss-Prot:Q8K1R7

Gene LinkOut

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