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Zfyve1 zinc finger, FYVE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 217695, updated on 11-Apr-2024

Summary

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Official Symbol
Zfyve1provided by MGI
Official Full Name
zinc finger, FYVE domain containing 1provided by MGI
Primary source
MGI:MGI:3026685
See related
Ensembl:ENSMUSG00000042628 AllianceGenome:MGI:3026685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DFCP1; TAFF1; ZNFN2A1; mKIAA1589; G630053K23
Summary
Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in lipid droplet formation. Located in several cellular components, including Golgi apparatus; lipid droplet; and mitochondrion. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.4), liver adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 38.76 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83593330..83679289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83546556..83597245, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:84716828-84716981 Neighboring gene STARR-positive B cell enhancer ABC_E3060 Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene RNA binding motif protein 25 Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene presenilin 1 Neighboring gene farnesyl diphosphate synthetase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding. Zhong X, et al. Cell Mol Immunol, 2020 Jul. PMID 31388100, Free PMC Article
  2. ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response. Zhong X, et al. PLoS Pathog, 2020 Apr. PMID 32251420, Free PMC Article
  3. Cellular localization and tissue distribution of endogenous DFCP1 protein. Nanao T, et al. Biomed Res, 2015. PMID 25876663
  4. DFCP1 associates with lipid droplets. Gao G, et al. Cell Biol Int, 2019 Dec. PMID 31293035
  5. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Li D, et al. Cell Rep, 2019 Apr 9. PMID 30970241

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
    Title: The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
  2. ZFYVE1 acts as a specific negative regulator of MDA5-mediated innate immune responses by inhibiting its ligand binding and oligomerization.
    Title: ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
  3. Endogenous DFCP1 was preferentially associated with mitochondria rather than with the Golgi apparatus or the endoplasmic reticulum in Hela cells.
    Title: Cellular localization and tissue distribution of endogenous DFCP1 protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of omegasome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in omegasome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359166.1 → NP_001346095.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA222714, AA422700, AC055772, AK139825, BB398888, BC050015, BY147113, BY256667, CF165708, CJ103131, CO043975
    Consensus CDS
    CCDS26028.1
    UniProtKB/Swiss-Prot
    Q3TC20, Q810J8
    UniProtKB/TrEMBL
    Q3UT32
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 121
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  2. NM_001359167.1 → NP_001346096.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA422700, AC055772, AC139382, AK090334
    Consensus CDS
    CCDS26028.1
    UniProtKB/Swiss-Prot
    Q3TC20, Q810J8
    UniProtKB/TrEMBL
    Q3UT32
    Related
    ENSMUSP00000152501.2, ENSMUST00000221919.2
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 121
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  3. NM_001359168.1 → NP_001346097.1  zinc finger FYVE domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA422700, AC139382, AK139825
    Conserved Domains (2) summary
    cd15734
    Location:296 → 356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:179 → 240
    FYVE_like_SF; FYVE domain like superfamily

  4. NM_001422984.1 → NP_001409913.1  zinc finger FYVE domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC055772, AC139382
    UniProtKB/Swiss-Prot
    Q3TC20, Q810J8

  5. NM_183154.4 → NP_898977.2  zinc finger FYVE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_898977.2

    Status: VALIDATED

    Source sequence(s)
    AA422700, AC055772, AC139382, BC050015
    Consensus CDS
    CCDS26028.1
    UniProtKB/Swiss-Prot
    Q3TC20, Q810J8
    UniProtKB/TrEMBL
    Q3UT32
    Related
    ENSMUSP00000042224.5, ENSMUST00000048319.6
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 121
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

RNA

  1. NR_186678.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC055772, AC139382

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    83593330..83679289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157320.1 → XP_036013213.1  zinc finger FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd15734
    Location:296 → 356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:179 → 240
    FYVE_like_SF; FYVE domain like superfamily

  2. XM_006515690.5 → XP_006515753.1  zinc finger FYVE domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515753.1

    UniProtKB/Swiss-Prot
    Q3TC20, Q810J8
    UniProtKB/TrEMBL
    Q3UT32
    Conserved Domains (5) summary
    cd01851
    Location:174 → 410
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd15734
    Location:711 → 771
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:594 → 655
    FYVE_like_SF; FYVE domain like superfamily
    cd19819
    Location:16 → 63
    Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
    cd19820
    Location:69 → 121
    Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

  3. XM_036157321.1 → XP_036013214.1  zinc finger FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd15734
    Location:296 → 356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:179 → 240
    FYVE_like_SF; FYVE domain like superfamily

  4. XM_030246658.2 → XP_030102518.1  zinc finger FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    cd15734
    Location:296 → 356
    FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
    cl28890
    Location:179 → 240
    FYVE_like_SF; FYVE domain like superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810J8.2 GenPept UniProtKB/Swiss-Prot:Q810J8

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